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ERO1A

ERO1-like protein alpha is a protein in humans that is encoded by ERO1A gene. Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

ERO1A Antibodies

ERO1A for Homo sapiens (Human)

ERO1A Proteins

ERO1A Proteins for Bos taurus (Bovine)

ERO1A Proteins for Sus scrofa (Pig)

ERO1A Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

ERO1A Proteins for Xenopus laevis (African clawed frog)

ERO1A Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ERO1A Proteins for Homo sapiens (Human)

ERO1A Proteins for Mus musculus (Mouse)

ERO1A Proteins for Rattus norvegicus (Rat)



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