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ERBB3

ERBB3,即人表皮生長因子受體3,別名HER3、CD340。ERBB3蛋白是一種酪氨酸激酶受體,屬于表皮生長因子受體家族,能與其他EGFR家族成員形成異源二聚體,從而激活下游信號通路,包括PI3K/AKT和MAPK/ERK通路,這些通路在細胞增殖、分化和生存中發揮重要作用。
ERBB3在多種正常生理過程中和腫瘤發展中扮演著關鍵角色,其過表達與多種癌癥(如乳腺癌、肺癌、結直腸癌等)的發生和進展密切相關,尤其是在HER2陽性乳腺癌中。ERBB3與HER2的相互作用被認為是腫瘤細胞增殖和轉移的促進因素。ERBB3是癌癥治療的重要靶點,靶向ERBB3的治療策略正在被廣泛研究,以期改善患者的預后和治療效果。

熱銷產品

Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) (CSB-MP007765HU)

驗證數據

CSB-MP007765HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007765HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1(CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.

EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)

驗證數據

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit (CSB-EL007765HU)

驗證數據

CSB-EL007765HU 標準曲線

貨號:CSB-EL007765HU

規格:96T/48T

靈敏度:31.25 pg/mL

檢測范圍:125 pg/mL-8000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ERBB3 Antibodies

ERBB3 for Homo sapiens (Human)

ERBB3 Proteins

ERBB3 Proteins for Homo sapiens (Human)

ERBB3 Proteins for Rattus norvegicus (Rat)

ERBB3 Proteins for Pongo abelii (Sumatran orangutan)

ERBB3 Proteins for Mus musculus (Mouse)

ERBB3 ELISA Kit

ERBB3 ELISA Kit for Homo sapiens (Human)



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