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EPHA2

EphA2,全稱為Erythropoietin-producing hepatocellular A2,是一種關鍵的受體酪氨酸激酶。它參與細胞信號轉導、細胞間相互作用以及組織發育等多種生物學過程。EphA2蛋白在胚胎發育中發揮重要作用,如調節血管生成、后腦發育和乳腺形態發生等。此外,它還與丙型肝炎病毒的感染機制相關,作為病毒受體促進病毒進入細胞。
近年來,EphA2蛋白在癌癥發生和發展中的作用逐漸被揭示。研究發現,EphA2蛋白在癌癥中具有雙重角色:一方面,它可以抑制癌癥的生長和擴散;另一方面,經過某些腫瘤相關蛋白修飾后,EphA2可能促進癌癥的發生。這種復雜性使得EphA2成為癌癥治療研究的重要靶點。目前,針對EphA2的靶向治療藥物正在研發中,有望為癌癥患者提供新的治療策略。

熱銷產品

Recombinant Human Ephrin type-A receptor 2 (EPHA2F), partial (Active) (CSB-MP007722HUd7)

驗證數據

CSB-MP007722HUd7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007722HUd7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Anti-EPHA2 recombinant antibody (CSB-RA007722MA1HU). The EC50 is 36.24-50.53 ng/mL.

CSB-MP007722HUd7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/ml can bind Human EFNA1 (CSB-MP007460HU). The EC50 is 5.859-7.758 ng/mL.

CSB-MP007722HUd7

The purity of EPHA2F was greater than 95% as determined by SEC-HPLC

EPHA2 Antibody (CSB-PA007722LA01HU)

驗證數據

CSB-PA007722LA01HU

IHC image of CSB-PA007722LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA007722LA01HU

Immunofluorescence staining of A549 cells with CSB-PA007722LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Ephrin type-A receptor 2(EPHA2) ELISA kit (CSB-EL007722HU)

驗證數據

CSB-EL007722HU 標準曲線

貨號:CSB-EL007722HU

規格:96T/48T

靈敏度:0.039 ng/mL

檢測范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

EPHA2 Antibodies

EPHA2 for Homo sapiens (Human)

EPHA2 Proteins

EPHA2 Proteins for Homo sapiens (Human)

EPHA2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

EPHA2 ELISA Kit

EPHA2 ELISA Kit for Homo sapiens (Human)



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