在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF2AK2

Interferon-induced, double-stranded RNA-activated protein kinase is a protein in humans that is encoded by EIF2AK2 gene. IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.

EIF2AK2 Antibodies

EIF2AK2 for Homo sapiens (Human)

EIF2AK2 Proteins

EIF2AK2 Proteins for Mus musculus (Mouse)

EIF2AK2 Proteins for Homo sapiens (Human)

EIF2AK2 Proteins for Rattus norvegicus (Rat)



主站蜘蛛池模板: 精品丰满人妻无套内射| 成熟老妇女毛茸茸的做性| 成人午夜福利视频后入| 无码精品人妻一区二区三区漫画| 色狠狠一区二区三区香蕉| 国产亚洲精品久久综合阿香| 精品亚洲国产成人av制服| 天天摸夜夜添夜夜无码| 男女吃奶做爰猛烈紧视频| 国产福利姬喷水福利在线观看| 亚洲色无码中文字幕手机在线| 精品一区二区久久久久久久网站| 精品人妻一区二区三区四区| 久久亚洲精品国产精品婷婷| 国产精品自在在线午夜免费| 欧美疯狂做受xxxx高潮| 色综合久久久久无码专区| 99视频精品全部免费免费观看| 日本免费高清线视频免费| 五月开心播播网| 97成人精品国语自产拍| 中文字幕 乱码 中文乱码视频| 在线看亚洲十八禁网站| 国产绳艺sm调教室论坛 | 日本一区二区三区免费播放| 日本三级在线观看免费| 内射巨臀欧美在线视频| 国产亚洲精品自在久久vr| 毛片免费视频观看| 国产精品乱码人妻一区二区三区| 被c到高潮疯狂喷水国产| 中文字幕人妻丝袜乱一区三区| 国产最新进精品视频| 国内熟女啪啪自拍| 欧美成人午夜免费影院手机在线看 | 四川丰满少妇被弄到高潮| 好男人社区www在线官网| 亚洲一卡一卡二新区迎热烈讨论| 久久久久人妻一区二区三区| 少妇熟女视频一区二区三区| 亚洲区小说区激情区图片区|