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DIABLO

DIABLO,即細胞凋亡誘導因子SMAC模擬蛋白,別名DBOH、DFNA64、SMAC3,由DIABLO基因編碼。它是一種位于線粒體間隙的蛋白質,在細胞應激反應中發揮作用。DIABLO的作用機制是通過模擬SMAC蛋白的功能,促進細胞凋亡,抑制IAPs(凋亡抑制蛋白)的活性,從而推動細胞程序性死亡。DIABLO在細胞對氧化應激、DNA損傷和其他形式的細胞壓力的響應中具有重要作用。生物學意義上,DIABLO參與調控細胞生存與死亡的平衡,其異常表達與多種疾病有關,包括癌癥、神經退行性疾病等,是細胞凋亡研究和相關疾病治療中的潛在靶點。

熱銷產品

Recombinant Human Diablo homolog, mitochondrial (DIABLO) (CSB-EP865113HU)

驗證數據

CSB-EP865113HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DIABLO Antibody (CSB-PA865113LA01HU)

驗證數據

CSB-PA865113LA01HU

Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA865113LA01HU at dilution of 1:100

CSB-PA865113LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA865113LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

DIABLO Antibodies

DIABLO for Homo sapiens (Human)

DIABLO Proteins

DIABLO Proteins for Xenopus laevis (African clawed frog)

DIABLO Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

DIABLO Proteins for Pongo abelii (Sumatran orangutan)

DIABLO Proteins for Homo sapiens (Human)

DIABLO Proteins for Mus musculus (Mouse)