DDX5
DDX5，即DEAD盒解旋酶5，別名P68。它是一種依賴(lài)ATP的RNA解旋酶，屬于DEAD盒解旋酶家族成員之一，主要分布在細(xì)胞核內(nèi)。DDX5的作用機(jī)制涉及催化雙鏈RNA解旋，參與基因轉(zhuǎn)錄的正負(fù)調(diào)節(jié)以及mRNA、rRNA和miRNA的合成、剪接和加工等過(guò)程。DDX5對(duì)多種轉(zhuǎn)錄因子具有激活作用，影響細(xì)胞增殖、分化、細(xì)胞骨架重塑和細(xì)胞凋亡等，同時(shí)在腫瘤細(xì)胞的發(fā)生、侵襲和遷移中發(fā)揮作用，是影響腫瘤相關(guān)信號(hào)通路的關(guān)鍵因子。此外，DDX5的功能缺失可通過(guò)影響microRNA 125b的表達(dá)水平，上調(diào)非經(jīng)典PRC1復(fù)合物里的RYBP，進(jìn)而影響體細(xì)胞重編程過(guò)程。
熱銷(xiāo)產(chǎn)品
Recombinant Human Probable ATP-dependent RNA helicase DDX5 (DDX5) (CSB-EP006630HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006630HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX5.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006630HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX5.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HepG2 cells using p68 RNA Helicase Polyclonal Antibody
DDX5 Antibodies
DDX5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA006630GA01HU | DDX5 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA006630ESR2HU | DDX5 Antibody | Human | ELISA, WB, IHC |
| CSB-PA003685 | DDX5 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA007714 | Phospho-DDX5 (Y593) Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-RA231179A0HU | DDX5 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC, IF, FC |
DDX5 Proteins
DDX5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP006630HU CSB-BP006630HU CSB-MP006630HU CSB-EP006630HU-B |
Recombinant Human Probable ATP-dependent RNA helicase DDX5 (DDX5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006630HU | Recombinant Human Probable ATP-dependent RNA helicase DDX5 (DDX5) | E.coli |
