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CTSB

組織蛋白酶B(Cathepsin B)是一種溶酶體半胱氨酸蛋白酶,常被簡(jiǎn)稱為CathB或CTSB。這種酶在正常生理狀態(tài)下負(fù)責(zé)降解受損蛋白質(zhì),維持細(xì)胞穩(wěn)態(tài),但在病理?xiàng)l件下可能促進(jìn)腫瘤侵襲與炎癥反應(yīng)。研究發(fā)現(xiàn),其過度激活會(huì)破壞細(xì)胞外基質(zhì),加速癌細(xì)胞穿透血管壁形成轉(zhuǎn)移灶,在乳腺癌、膠質(zhì)瘤等多種惡性腫瘤中呈現(xiàn)高表達(dá)特征。此外,該蛋白酶還參與阿爾茨海默病的β淀粉樣蛋白沉積過程,并能激活炎癥小體加重類風(fēng)濕性關(guān)節(jié)炎。

近年來針對(duì)CTSB的藥物開發(fā)聚焦于特異性抑制劑,例如CA-074系列化合物已顯示出阻斷腫瘤轉(zhuǎn)移的潛力。部分研究嘗試將CTSB抑制劑與免疫檢查點(diǎn)療法聯(lián)用,通過調(diào)控腫瘤微環(huán)境增強(qiáng)抗PD-1治療效果。在神經(jīng)退行性疾病領(lǐng)域,小分子抑制劑Esteya表現(xiàn)出抑制tau蛋白異常磷酸化的作用,目前處于臨床前研究階段。值得注意的是,新冠病毒感染研究中發(fā)現(xiàn)CTSB可能參與病毒刺突蛋白的切割激活,這為抗病毒藥物研發(fā)提供了新思路。

熱銷產(chǎn)品

Recombinant Human Cathepsin B (CTSB), partial (CSB-EP006185HU1e1)

驗(yàn)證數(shù)據(jù)

CSB-EP006185HU1e1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTSB Antibody (CSB-PA06974A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA06974A0Rb

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06974A0Rb at dilution of 1:100

CSB-PA06974A0Rb

Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue
All lanes: CTSB antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa

CSB-PA06974A0Rb

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA06974A0Rb at dilution of 1:100

CSB-PA06974A0Rb

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA06974A0Rb at dilution of 1:100

CSB-PA06974A0Rb

Immunofluorescent analysis of A375 cells using CSB-PA06974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human cathepsin B (CTSB) ELISA kit (CSB-E13450h)

驗(yàn)證數(shù)據(jù)

CSB-E13450h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E13450h

規(guī)格:96T/48T

靈敏度:0.078 ng/mL

檢測(cè)范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CTSB Antibodies

CTSB for Homo sapiens (Human)

CTSB Proteins

CTSB Proteins for Ovis aries (Sheep)

CTSB Proteins for Mus musculus (Mouse)

CTSB Proteins for Gallus gallus (Chicken)

CTSB Proteins for Rattus norvegicus (Rat)

CTSB Proteins for Homo sapiens (Human)

CTSB Proteins for Bos taurus (Bovine)

CTSB Proteins for Sus scrofa (Pig)

CTSB Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

CTSB Proteins for Dictyostelium discoideum (Slime mold)

CTSB Proteins for Pongo abelii (Sumatran orangutan)

CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CTSB ELISA Kit

CTSB ELISA Kit for Mus musculus (Mouse)

CTSB ELISA Kit for Rattus norvegicus (Rat)

CTSB ELISA Kit for Homo sapiens (Human)