CTSB
組織蛋白酶B（Cathepsin B）是一種溶酶體半胱氨酸蛋白酶，常被簡(jiǎn)稱為CathB或CTSB。這種酶在正常生理狀態(tài)下負(fù)責(zé)降解受損蛋白質(zhì)，維持細(xì)胞穩(wěn)態(tài)，但在病理?xiàng)l件下可能促進(jìn)腫瘤侵襲與炎癥反應(yīng)。研究發(fā)現(xiàn)，其過度激活會(huì)破壞細(xì)胞外基質(zhì)，加速癌細(xì)胞穿透血管壁形成轉(zhuǎn)移灶，在乳腺癌、膠質(zhì)瘤等多種惡性腫瘤中呈現(xiàn)高表達(dá)特征。此外，該蛋白酶還參與阿爾茨海默病的β淀粉樣蛋白沉積過程，并能激活炎癥小體加重類風(fēng)濕性關(guān)節(jié)炎。
近年來針對(duì)CTSB的藥物開發(fā)聚焦于特異性抑制劑，例如CA-074系列化合物已顯示出阻斷腫瘤轉(zhuǎn)移的潛力。部分研究嘗試將CTSB抑制劑與免疫檢查點(diǎn)療法聯(lián)用，通過調(diào)控腫瘤微環(huán)境增強(qiáng)抗PD-1治療效果。在神經(jīng)退行性疾病領(lǐng)域，小分子抑制劑Esteya表現(xiàn)出抑制tau蛋白異常磷酸化的作用，目前處于臨床前研究階段。值得注意的是，新冠病毒感染研究中發(fā)現(xiàn)CTSB可能參與病毒刺突蛋白的切割激活，這為抗病毒藥物研發(fā)提供了新思路。
熱銷產(chǎn)品
Recombinant Human Cathepsin B (CTSB), partial (CSB-EP006185HU1e1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CTSB Antibody (CSB-PA06974A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06974A0Rb at dilution of 1:100
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue
All lanes: CTSB antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA06974A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA06974A0Rb at dilution of 1:100
Immunofluorescent analysis of A375 cells using CSB-PA06974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human cathepsin B (CTSB) ELISA kit (CSB-E13450h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E13450h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CTSB Antibodies
CTSB for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06974A0Rb | CTSB Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA06974B0Rb | CTSB Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06974C0Rb | CTSB Antibody, FITC conjugated | Human | |
| CSB-PA06974D0Rb | CTSB Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006185GA01HU | CTSB Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001296 | CTSB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA047604 | CTSB Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA825136 | CTSB Antibody | Human,Mouse,Rat | ELISA,IHC |
CTSB Proteins
CTSB Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185SH CSB-EP006185SH CSB-BP006185SH CSB-MP006185SH CSB-EP006185SH-B |
Recombinant Sheep Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185MO CSB-EP006185MO CSB-BP006185MO CSB-MP006185MO CSB-EP006185MO-B |
Recombinant Mouse Cathepsin B (Ctsb) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185CH CSB-EP006185CH CSB-BP006185CH CSB-MP006185CH CSB-EP006185CH-B |
Recombinant Chicken Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185RA CSB-EP006185RA CSB-BP006185RA CSB-MP006185RA CSB-EP006185RA-B |
Recombinant Rat Cathepsin B (Ctsb) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP006185HU CSB-BP006185HU CSB-MP006185HU CSB-EP006185HU-B |
Recombinant Human Cathepsin B (CTSB) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006185HU1 | Recombinant Human Cathepsin B (CTSB), partial | E.coli |
| CSB-AP005381HU | Recombinant Human Cathepsin B (CTSB), partial (Active) | Mammalian cell |
| CSB-EP006185HU1e1 | Recombinant Human Cathepsin B (CTSB), partial | E.coli |
| CSB-YP006185HU | Recombinant Human Cathepsin B (CTSB) | Yeast |
| CSB-MP006185HU3(M) | Recombinant Human Cathepsin B (CTSB)(L26V) | Mammalian cell |
CTSB Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185BO CSB-EP006185BO CSB-BP006185BO CSB-MP006185BO CSB-EP006185BO-B |
Recombinant Bovine Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185PI CSB-EP006185PI CSB-BP006185PI CSB-MP006185PI CSB-EP006185PI-B |
Recombinant Pig Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185DXJ CSB-EP006185DXJ CSB-BP006185DXJ CSB-MP006185DXJ CSB-EP006185DXJ-B |
Recombinant Coturnix coturnix japonica Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185DKK CSB-EP006185DKK CSB-BP006185DKK CSB-MP006185DKK CSB-EP006185DKK-B |
Recombinant Dictyostelium discoideum Cathepsin B (ctsB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185PYX CSB-EP006185PYX CSB-BP006185PYX CSB-MP006185PYX CSB-EP006185PYX-B |
Recombinant Pongo abelii Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006185MOV CSB-EP006185MOV CSB-BP006185MOV CSB-MP006185MOV CSB-EP006185MOV-B |
Recombinant Macaca fascicularis Cathepsin B (CTSB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTSB ELISA Kit
CTSB ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006185MO | Mouse Cathepsin B(CTSB) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
CTSB ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006185RA | Rat Cathepsin B(CTSB) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 4.67 ng/mL |
CTSB ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13450h | Human cathepsin B (CTSB) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
