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CLPTM1L

CLPTM1L,全稱 Cleft Lip and Palate Transmembrane Protein 1-Like,常見別名包括 CRR9p 和 CLPTM1-like 蛋白。該蛋白主要表達于皮膚、肺和胰腺等組織中,定位于高爾基體和內質網,參與細胞內的囊泡運輸和蛋白質分選過程。研究表明,CLPTM1L 蛋白可能通過抑制細胞凋亡促進細胞存活,并與端粒酶活性調節相關,影響細胞衰老和增殖。該蛋白的異常表達或突變與多種癌癥風險增加有關,特別是肺癌、胰腺癌和卵巢癌。例如,在非小細胞肺癌中,CLPTM1L 蛋白的高表達與較差的預后相關。因此,CLPTM1L 蛋白已成為潛在的診斷標志物和治療靶點。目前,針對 CLPTM1L 蛋白的藥物研發尚處于探索階段,但已有研究表明,抑制 CLPTM1L 蛋白可以抑制腫瘤發生,而提高其表達則可能增加細胞對凋亡信號的敏感性。

熱銷產品

CLPTM1L Antibody (CSB-PA850323LA01HU)

驗證數據

CSB-PA850323LA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: CLPTM1L antibody at 3.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63, 59 kDa
Observed band size: 63 kDa

CSB-PA850323LA01HU

IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA850323LA01HU

IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA850323LA01HU

Immunofluorescence staining of A549 cells with CSB-PA850323LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CLPTM1L Antibodies

CLPTM1L for Homo sapiens (Human)

CLPTM1L Proteins

CLPTM1L Proteins for Homo sapiens (Human)