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CLDN4

CLDN4:作為潛力腫瘤治療靶標,展示聯合用藥潛力

Claudin 4( CLDN4 )是一種緊密連接蛋白,是Claudin 家族的一員,Claudin 蛋白均由4個跨膜結構域構成,N端和C端均位于細胞內部,細胞膜外有2個長度不等的環,可以和臨近其他同類型的環相接觸構成細胞間的緊密連接. 而且CLDN4的結構高度保守,從線蟲到人類都十分相似.當Claudin蛋白發生變化時將影響細胞間的通透性進一步引起多種疾病的發生.研究報道CLDN4 在卵巢癌、前列腺癌、乳腺癌、胰腺癌、腸道癌等多種腫瘤中表達上調,并且作為一種癌基因介導癌癥的發生。

CUSABIO-哺乳包膜VIPs平臺成功開發CLDN4全長跨膜蛋白(4次跨膜),展示了完整生物活性。

熱銷產品

Recombinant Human Claudin-4(CLDN4)-VLPs (Active) (CSB-MP005506HU)

驗證數據

WB驗證蛋白特異性

CSB-MP005506HU is detected by Mouse anti-6*His monoclonal antibody.

功能性ELISA驗證抗原抗體結合活性

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN4 at 5 μg/ml can bind Anti-CLDN4 recombinant antibody (CSB-RA005506MA1HU), the EC50 is 29.56-50.75 ng/mL

CLDN4 Recombinant Monoclonal Antibody CSB-RA005506MA2HU

驗證數據

FC
CSB-RA005506MA2HU FC

Overlay Peak curve showing MCF7 cells stained with CSB-RA005506MA2HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CLDN4 Antibodies

CLDN4 for Homo sapiens (Human)

CLDN4 Proteins

CLDN4 Proteins for Homo sapiens (Human)

CLDN4 Proteins for Mus musculus (Mouse)

CLDN4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CLDN4 Proteins for Bos taurus (Bovine)

CLDN4 ELISA Kit

CLDN4 ELISA Kit for Homo sapiens (Human)