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CHRM1

CHRM1,即膽堿能受體毒蕈堿1,別名包括毒蕈堿M1受體、乙酰膽堿受體毒蕈堿1。它是一種G蛋白偶聯(lián)受體,由CHRM1基因編碼,在中樞神經(jīng)系統(tǒng)、視網(wǎng)膜和泌尿系統(tǒng)中表達(dá)。CHRM1的作用機(jī)制主要是通過與乙酰膽堿結(jié)合,激活G蛋白,進(jìn)而抑制腺苷酸環(huán)化酶活性、促進(jìn)磷酸肌醇的降解和調(diào)節(jié)鉀通道,從而介導(dǎo)多種細(xì)胞反應(yīng)。CHRM1在生物學(xué)上的意義非常廣泛,它參與調(diào)節(jié)迷走神經(jīng)誘導(dǎo)的支氣管收縮、胃腸道的酸分泌以及認(rèn)知功能等。此外,CHRM1的功能異常與多種疾病有關(guān),包括Lambert-Eaton肌無力綜合征、哮喘、重癥肌無力、焦慮癥、心傳導(dǎo)阻滯、帕瑞特腺癌、阿爾茨海默病、精神分裂癥等。

熱銷產(chǎn)品

Recombinant Human Muscarinic acetylcholine receptor M1 (CHRM1), partial (CSB-EP005381HU1)

驗證數(shù)據(jù)

CSB-EP005381HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CHRM1 Antibody (CSB-PA576885)

驗證數(shù)據(jù)

CSB-PA576885

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA576885(CHRM1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA576885

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA576885(CHRM1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

CHRM1 Antibodies

CHRM1 for Rattus norvegicus (Rat)

CHRM1 for Homo sapiens (Human)

CHRM1 Proteins

CHRM1 Proteins for Homo sapiens (Human)

CHRM1 Proteins for Mus musculus (Mouse)

CHRM1 Proteins for Macaca mulatta (Rhesus macaque)

CHRM1 Proteins for Sus scrofa (Pig)

CHRM1 Proteins for Pongo abelii (Sumatran orangutan)

CHRM1 Proteins for Rattus norvegicus (Rat)

CHRM1 ELISA Kit

CHRM1 ELISA Kit for Rattus norvegicus (Rat)