CHMP4A
CHMP4A,全名為Charged Multivesicular Body Protein 4A,常見別名包括C14orf123抗體、Charged multivesicular body protein 4a抗體、Chromatin modifying protein 4a抗體等。該蛋白屬于染色質(zhì)修飾蛋白/帶電荷多泡體蛋白家族,是轉(zhuǎn)運(yùn)必需內(nèi)吞體分選復(fù)合物III的主要組份,參與多泡體的生物合成和病毒出芽。CHMP4A在肺癌細(xì)胞系中較高表達(dá),在前列腺癌和乳腺癌中,其表達(dá)與HIF1A明顯負(fù)相關(guān),提示其在相關(guān)腫瘤組織中高表達(dá)可能是個(gè)好的診斷標(biāo)志物。研究發(fā)現(xiàn)CHMP4A能增加/穩(wěn)定HIF-1α的蛋白表達(dá),并增強(qiáng)HIF-1下游靶基因VEGF和AK3的轉(zhuǎn)錄活性,進(jìn)而促進(jìn)細(xì)胞增殖及克隆形成能力。體內(nèi)實(shí)驗(yàn)的初步結(jié)果也顯示CHMP4A對(duì)于肺癌的發(fā)生發(fā)展有促進(jìn)作用。目前,針對(duì)CHMP4A蛋白的藥物研發(fā)尚處于探索階段,但其在腫瘤診斷和治療中的應(yīng)用前景值得期待。
CHMP4A Proteins
CHMP4A Proteins for Bos taurus (Bovine)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP005362BO CSB-EP005362BO CSB-BP005362BO CSB-MP005362BO CSB-EP005362BO-B |
Recombinant Bovine Charged multivesicular body protein 4a (CHMP4A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CHMP4A Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP883630HU CSB-EP883630HU CSB-BP883630HU CSB-MP883630HU CSB-EP883630HU-B |
Recombinant Human Charged multivesicular body protein 4a (CHMP4A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |