CDH11
CDH11,即鈣黏蛋白11(Cadherin-11),屬于鈣依賴性跨膜黏附蛋白家族,又稱OB-cadherin或OSF-4,在胚胎發育階段主導間充質細胞定向遷移,成年后主要分布于成骨細胞、滑膜細胞及腫瘤微環境中。CDH11通過介導細胞間機械連接參與骨重塑、關節形成及組織纖維化進程,其異常表達與骨關節炎、類風濕性關節炎密切相關,臨床研究發現患者滑膜中CDH11表達水平顯著升高。在腫瘤領域,CDH11促進乳腺癌、前列腺癌的骨轉移,并通過激活PI3K/AKT通路增強腫瘤細胞侵襲性。目前針對CDH11的靶向治療已取得突破,如單克隆抗體RG6125在類風濕性關節炎II期試驗中展現出抑制骨侵蝕的潛力,而小分子抑制劑EF-626通過阻斷CDH1-CD11相互作用,在動物模型中有效減少腫瘤骨轉移灶形成。近期研究還發現CDH11與特發性肺纖維化存在關聯,相關抗體藥物已進入臨床前評估階段。
熱銷產品
CDH11 Recombinant Monoclonal Antibody (CSB-RA005036MA1HU)
驗證數據

Immunofluorescence?staining?of?Hela?cell?with?CSB-RA005036MA1HU?at?1:10,?counter-stained?with?DAPI.?The?cells?were?fixed?in?4%?formaldehyde?and?blocked?in?10%?normal?Goat?Serum.?The?cells?were?then?incubated?with?the?antibody?overnight?at?4C.?The?secondary?antibody?was?FITC-conjugated?AffiniPure?Goat?Anti-Human?IgG(H+L).
CDH11 Antibodies
CDH11 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA905632 | CDH11 Antibody | Human,Mouse | ELISA,WB |
CSB-PA005036ESR1HU | CDH11 Antibody | Human | ELISA, WB, IHC, IP |
CSB-PA005036ESR2HU | CDH11 Antibody | Human | ELISA, IHC |
CSB-PA006384 | CDH11 Antibody | Human,Mouse | WB, ELISA |
CSB-PA005036EA01HU | CDH11 Antibody | Human | ELISA, IHC, IF |
CSB-PA005036ED01HU | CDH11 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA005036MA1HU | CDH11 Recombinant Monoclonal Antibody | Human | ELISA, IF |
CDH11 Proteins
CDH11 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP005036HU1 CSB-EP005036HU1 CSB-BP005036HU1 CSB-MP005036HU1 CSB-EP005036HU1-B |
Recombinant Human Cadherin-11 (CDH11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF005036HU(A4) | Recombinant Human Cadherin-11 (CDH11) | in vitro E.coli expression system |