BCAM
BCAM蛋白全稱為基底細胞黏附分子,也被稱為Lutheran血型抗原或CD239,是一種跨膜糖蛋白。該蛋白主要表達于紅細胞、上皮細胞及多種腫瘤細胞表面,通過與細胞外基質中的層粘連蛋白結合參與細胞黏附及遷移過程。研究發現BCAM在鐮狀細胞病中異常活躍,其與血管內皮細胞的相互作用加劇了紅細胞的滯留,導致血管阻塞危象的發生。在惡性腫瘤領域,BCAM的高表達與卵巢癌、胰腺癌的轉移密切相關,可能通過激活特定激酶促進腫瘤細胞侵襲。近年來針對BCAM的靶向治療逐漸受到關注,已有研究團隊開發出阻斷BCAM與層粘連蛋白結合的單克隆抗體,在動物模型中顯示出抑制腫瘤轉移的效果。2022年一項針對鐮狀細胞病的II期臨床試驗中,BCAM抑制劑聯合抗凝血療法使患者疼痛危象發生率降低40%,目前該靶點的雙功能抗體藥物已進入臨床前評估階段。
熱銷產品
BCAM Antibody (CSB-PA341920LA01HU)
驗證數據

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
BCAM Antibodies
BCAM for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA005864 | BCAM Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA908140 | BCAM Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA930807 | BCAM Antibody | Human | ELISA,WB |
CSB-PA341920LA01HU | BCAM Antibody | Human | ELISA, IHC, IF |
BCAM Proteins
BCAM Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP341920HU CSB-EP341920HU CSB-BP341920HU CSB-MP341920HU CSB-EP341920HU-B |
Recombinant Human Basal cell adhesion molecule (BCAM), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |