BATF3
BATF3，即堿性亮氨酸拉鏈ATF樣轉(zhuǎn)錄因子3，別名JDP1、SNFT、JUNDM1。它是一種由人類BATF3基因編碼的轉(zhuǎn)錄因子，屬于基本亮氨酸拉鏈蛋白家族。BATF3在多種免疫細(xì)胞的發(fā)育和功能中發(fā)揮作用，尤其在樹(shù)突狀細(xì)胞和CD8+T細(xì)胞中。其作用機(jī)制涉及與JUN蛋白異二聚化，形成轉(zhuǎn)錄抑制復(fù)合物，調(diào)控下游基因的表達(dá)，如通過(guò)抑制白細(xì)胞介素2和基質(zhì)金屬蛋白酶1的轉(zhuǎn)錄。BATF3在免疫應(yīng)答中扮演關(guān)鍵角色，影響T細(xì)胞的存活、記憶形成和抗腫瘤免疫反應(yīng)。BATF3的異常表達(dá)與多種疾病相關(guān)，包括某些類型的白血病和免疫缺陷。BATF3是研究免疫相關(guān)疾病和開(kāi)發(fā)相應(yīng)治療策略的重要靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western blot analysis of mouse-lung mouse-spleen lysis using BATF3 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
BATF3 Antibodies
BATF3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA882082LA01HU | BATF3 Antibody | Human | ELISA, IF |
| CSB-PA882082LC01HU | BATF3 Antibody, FITC conjugated | Human | |
| CSB-PA344549 | BATF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
BATF3 Proteins
BATF3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882082HU CSB-EP882082HU CSB-BP882082HU CSB-MP882082HU CSB-EP882082HU-B |
Recombinant Human Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
