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ATG5

ATG5,全稱自噬相關(guān)5蛋白,是細(xì)胞自噬過程中的關(guān)鍵參與者。該蛋白常見別名為APG5L,在自噬體形成中發(fā)揮重要作用。ATG5通過與ATG12結(jié)合,形成ATG12-ATG5復(fù)合物,進(jìn)而參與自噬體的隔離膜形成。這一過程對于細(xì)胞內(nèi)受損細(xì)胞器、錯誤折疊蛋白質(zhì)和病原體的清除至關(guān)重要,維持細(xì)胞穩(wěn)態(tài)。ATG5的表達(dá)在細(xì)胞凋亡過程中相對較晚出現(xiàn),通常在caspase活性下游高表達(dá),提示其在凋亡過程中也扮演一定角色。
ATG5與多種疾病相關(guān),包括神經(jīng)退行性疾病和癌癥。在藥物研發(fā)方面,已有研究團(tuán)隊(duì)致力于開發(fā)靶向ATG5相關(guān)蛋白-蛋白相互作用的小分子抑制劑,以調(diào)控自噬過程,為相關(guān)疾病的治療提供新策略。例如,南方醫(yī)科大學(xué)何翔教授團(tuán)隊(duì)發(fā)現(xiàn),環(huán)狀RNA CircHipk3通過抑制自噬相關(guān)蛋白Atg5和Beclin1,加劇了巨噬細(xì)胞焦亡,從而促進(jìn)腹主動脈瘤的形成,為該疾病的治療提供了潛在靶點(diǎn)。這些研究進(jìn)展表明,ATG5及其相關(guān)通路是疾病治療的重要方向。

熱銷產(chǎn)品

ATG5 Antibody (CSB-PA15499A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA15499A0Rb

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA15499A0Rb at dilution of 1:100

CSB-PA15499A0Rb

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA15499A0Rb at dilution of 1:100

CSB-PA15499A0Rb

Immunofluorescent analysis of MCF-7 cells using CSB-PA15499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

ATG5 Antibodies

ATG5 for Homo sapiens (Human)

ATG5 Proteins

ATG5 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

ATG5 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)

ATG5 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

ATG5 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

ATG5 Proteins for Oryza sativa subsp. indica (Rice)

ATG5 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)

ATG5 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)

ATG5 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

ATG5 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

ATG5 Proteins for Ajellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)

ATG5 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)

ATG5 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)

ATG5 Proteins for Pichia angusta (Yeast) (Hansenula polymorpha)

ATG5 Proteins for Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)

ATG5 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ATG5 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

ATG5 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)

ATG5 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ATG5 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)

ATG5 Proteins for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)

ATG5 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

ATG5 Proteins for Sus scrofa (Pig)

ATG5 Proteins for Bos taurus (Bovine)

ATG5 Proteins for Rattus norvegicus (Rat)

ATG5 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

ATG5 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

ATG5 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

ATG5 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

ATG5 Proteins for Dictyostelium discoideum (Slime mold)

ATG5 Proteins for Pongo abelii (Sumatran orangutan)

ATG5 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

ATG5 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

ATG5 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

ATG5 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

ATG5 Proteins for Oryza sativa subsp. japonica (Rice)

ATG5 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

ATG5 Proteins for Mus musculus (Mouse)

ATG5 Proteins for Homo sapiens (Human)

ATG5 Proteins for Arabidopsis thaliana (Mouse-ear cress)

ATG5 Proteins for Drosophila melanogaster (Fruit fly)