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ALOX5

ALOX5,即花生四烯酸5-脂氧合酶,別名Arachidonate 5-lipoxygenase。它屬于脂氧合酶家族成員,由人體細胞自身編碼產生。ALOX5在多種細胞類型中都有表達,特別是在骨髓衍生的細胞中表達量較高。其作用機制主要是催化花生四烯酸轉化為5(S)-HPETE,進而生成白三烯A4(LTA4),這是白三烯生物合成途徑中的起始和關鍵步驟。白三烯是一類重要的炎癥介質,參與多種炎癥和過敏反應的調控。ALOX5的活性受到多種因素的調控,包括細胞因子、應激反應和細胞內信號分子等。ALOX5在生物學上的意義主要體現在其對炎癥反應的調控作用。它不僅參與了白三烯的合成,影響炎癥和免疫過程,還可能參與脂質過氧化和細胞死亡模式的調控,如凋亡、焦亡和鐵死亡。ALOX5的表達或活性異常與多種疾病的發生發展有關,包括哮喘、動脈粥樣硬化、腫瘤等。此外,ALOX5還可能作為腫瘤免疫微環境中的一個重要因素,影響腫瘤的免疫細胞浸潤和免疫治療的效果,因此,它也是藥物開發和疾病治療中的一個潛在靶點。

熱銷產品

Recombinant Human Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) (CSB-CF001625HU)

驗證數據

CSB-CF001625HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALOX5 Recombinant Monoclonal Antibody (CSB-RA198316A0HU)

驗證數據

CSB-RA198316A0HU

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA198316A0HU

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ALOX5 Antibodies

ALOX5 for Homo sapiens (Human)

ALOX5 Proteins

ALOX5 Proteins for Rattus norvegicus (Rat)

ALOX5 Proteins for Mus musculus (Mouse)

ALOX5 Proteins for Homo sapiens (Human)

ALOX5 Proteins for Mesocricetus auratus (Golden hamster)

ALOX5 ELISA Kit

ALOX5 ELISA Kit for Rattus norvegicus (Rat)



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