ADIPOR2
脂聯(lián)素受體2(Adiponectin Receptor 2,簡(jiǎn)稱ADIPOR2),也被稱為PAQR2或ACDCR2。它屬于孕激素和adipoQ受體家族,與G蛋白偶聯(lián)受體類似,擁有7個(gè)跨膜結(jié)構(gòu)域,但膜上方向相反。ADIPOR2主要在肝臟和骨骼肌中表達(dá),負(fù)責(zé)結(jié)合脂聯(lián)素,一種由脂肪細(xì)胞分泌的激素,激活A(yù)MPK和PPAR-α通路,促進(jìn)脂肪酸氧化和葡萄糖攝取,從而改善胰島素抵抗并減少炎癥反應(yīng)。ADIPOR2的功能特點(diǎn)包括調(diào)控糖脂代謝平衡、抑制肝臟糖異生以及增強(qiáng)線粒體功能。若ADIPOR2發(fā)生突變,可能導(dǎo)致受體功能喪失或減弱,引發(fā)代謝異常,如2型糖尿病、肥胖和非酒精性脂肪肝病(NAFLD)。
ADIPOR2基因多態(tài)性與代謝綜合征風(fēng)險(xiǎn)相關(guān)。當(dāng)ADIPOR2過(guò)表達(dá)時(shí),可增強(qiáng)胰島素敏感性并減少脂肪堆積;而低表達(dá)則可能加劇代謝紊亂,誘發(fā)高血糖和血脂異常。ADIPOR2還與其他基因相互作用,共同調(diào)控代謝途徑。目前,ADPN重組蛋白或其受體激活蛋白可能作為有效的干預(yù)形式,被開(kāi)發(fā)為藥物,治療細(xì)胞和動(dòng)物在疾病模型中的糖脂代謝紊亂,并在人體臨床試驗(yàn)表現(xiàn)出抗糖尿病、抗動(dòng)脈粥樣硬化和抗炎的潛力。此外,ADIPOR2還可能是糖尿病和冠心病等糖脂代謝異常疾病的標(biāo)志物。
熱銷產(chǎn)品
ADIPOR2 Antibody (CSB-PA011355)
驗(yàn)證數(shù)據(jù)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA011355(ADIPOR2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA011355(ADIPOR2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
ADIPOR2 Antibodies
ADIPOR2 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA001368GA01HU | ADIPOR2 Antibody | Human,Mouse,Rat | ELISA,WB,IP,IHC |
CSB-PA011355 | ADIPOR2 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA141929 | ADIPOR2 Antibody | Human,Mouse | ELISA,IHC |
ADIPOR2 Proteins
ADIPOR2 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP768214HU1 CSB-EP768214HU1 CSB-BP768214HU1 CSB-MP768214HU1 CSB-EP768214HU1-B |
Recombinant Human Adiponectin receptor protein 2 (ADIPOR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF768214HU | Recombinant Human Adiponectin receptor protein 2 (ADIPOR2) | in vitro E.coli expression system |
ADIPOR2 Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP805321MO1 CSB-EP805321MO1 CSB-BP805321MO1 CSB-MP805321MO1 CSB-EP805321MO1-B |
Recombinant Mouse Adiponectin receptor protein 2 (Adipor2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF805321MO | Recombinant Mouse Adiponectin receptor protein 2 (Adipor2) | in vitro E.coli expression system |