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ADGRE5

ADGRE5(Adhesion G Protein-Coupled Receptor E5)又名CD97,屬于粘附類G蛋白偶聯(lián)受體家族,其蛋白結(jié)構(gòu)包含胞外EGF樣結(jié)構(gòu)域和跨膜七次螺旋結(jié)構(gòu),能夠通過結(jié)合補體調(diào)節(jié)蛋白CD55等配體介導(dǎo)細(xì)胞間黏附。該蛋白在單核細(xì)胞、巨噬細(xì)胞等免疫細(xì)胞中高表達(dá),參與調(diào)控炎癥反應(yīng)、細(xì)胞遷移及免疫微環(huán)境重塑。ADGRE5通過激活Wnt/β-catenin、PI3K/AKT等通路,與結(jié)直腸癌、胰腺癌等實體瘤的侵襲轉(zhuǎn)移密切相關(guān),其過表達(dá)可促進(jìn)腫瘤血管生成和免疫逃逸。在動脈粥樣硬化領(lǐng)域,ADGRE5通過與血管平滑肌細(xì)胞相互作用加速斑塊進(jìn)展。近年來針對該靶點的藥物開發(fā)聚焦于單克隆抗體和拮抗肽,已有研究團(tuán)隊開發(fā)出阻斷CD97-CD55互作的抗體藥物,在動物模型中顯示出抑制腫瘤轉(zhuǎn)移的效果。

熱銷產(chǎn)品

CD97 Recombinant Monoclonal Antibody (CSB-RA004972A0HU)

驗證數(shù)據(jù)

CSB-RA004972A0HU

IHC image of CSB-RA004972A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA004972A0HU

IHC image of CSB-RA004972A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA004972A0HU

Immunofluorescence staining of Hela cells with CSB-RA004972A0HU at 1:87.5,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

ADGRE5 Antibodies

ADGRE5 for Homo sapiens (Human)

ADGRE5 Proteins

ADGRE5 Proteins for Homo sapiens (Human)

ADGRE5 Proteins for Bos taurus (Bovine)