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ACHE

ACHE,即乙酰膽堿酯酶,別名AChE,是生物神經(jīng)傳導(dǎo)中的一種關(guān)鍵性酶。它主要來(lái)源于生物體內(nèi),特別是在膽堿能突觸間隙中發(fā)揮作用。ACHE的作用機(jī)制是通過(guò)降解乙酰膽堿(ACh),從而終止神經(jīng)遞質(zhì)對(duì)突觸后膜的興奮作用,保證神經(jīng)信號(hào)在生物體內(nèi)的正常傳遞。此外,ACHE還參與細(xì)胞的發(fā)育和成熟,促進(jìn)神經(jīng)元發(fā)育和神經(jīng)再生。ACHE與多種疾病如阿爾茲海默病、肝癌等密切相關(guān)。例如,在阿爾茲海默病中,抑制ACHE可以增加ACh的累積,從而緩解認(rèn)知障礙。而在肝癌中,ACHE的低表達(dá)與肝癌細(xì)胞的生長(zhǎng)和體內(nèi)成瘤能力有關(guān),提示其作為肝癌預(yù)后因子的潛力。

熱銷(xiāo)產(chǎn)品

Recombinant Human Acetylcholinesterase (ACHE) (CSB-MP001154HU)

驗(yàn)證數(shù)據(jù)

CSB-MP001154HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ACHE Antibody (CSB-PA5619A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA5619A0Rb

IHC image of CSB-PA5619A0Rb diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA5619A0Rb

Immunofluorescence staining of MCF-7 cells with CSB-PA5619A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ACHE Antibodies

ACHE for Homo sapiens (Human)

ACHE Proteins

ACHE Proteins for Homo sapiens (Human)

ACHE ELISA Kit

ACHE ELISA Kit for Homo sapiens (Human)



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