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GLP1R

GLP1R,全稱為胰高血糖素樣肽-1受體,是一種在調(diào)節(jié)血糖方面發(fā)揮重要作用的受體蛋白。該蛋白也被稱為GLP-1受體的別名。GLP1R主要分布在胰島β細胞、胃、小腸、心臟、腎臟、肺和大腦等組織器官中。當(dāng)GLP1R被胰高血糖素樣肽-1(GLP-1)或人工合成的GLP-1R激動劑激活后,能夠促進胰島β細胞的增殖,刺激胰島素的合成與釋放,并抑制胰高血糖素的合成與釋放。此外,GLP1R還能抑制胃液分泌和胃腸道的蠕動,延遲胃的排空,增加飽腹感,減少食物攝取。近年來,GLP1R激動劑類藥物在治療2型糖尿病和肥胖癥方面取得了顯著成效,市場規(guī)模不斷增長。目前,全球已有多款GLP1R激動劑類藥物上市,它們不僅降糖效果顯著,同時還兼具減重、降壓、改善血脂譜等作用。未來,隨著GLP1R藥物研發(fā)的不斷深入,其在治療2型糖尿病和肥胖癥方面的應(yīng)用前景將更加廣闊。

熱銷產(chǎn)品

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)

驗證數(shù)據(jù)

CSB-MP009514HUb1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514HUb1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.

GLP1R monoclonal antibody (CSB-RA009514MA1HU)

驗證數(shù)據(jù)

CSB-RA009514MA1HU

The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.

CSB-RA009514MA1HU

Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA009514MA1HU

Positive WB detected in: MCF-7 whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 300s

GLP1R Antibody (CSB-PA009514YA01HU)

驗證數(shù)據(jù)

CSB-PA009514YA01HU

Western blot
All lanes: GLP1R antibody at 12µg/ml
Lane 1: Mouse heart tissue
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

CSB-PA009514YA01HU

Immunofluorescent analysis of 293T cells using CSB-PA009514YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GLP1R Antibodies

GLP1R for Homo sapiens (Human)

GLP1R for Mus musculus (Mouse)

GLP1R Proteins

GLP1R Proteins for Rattus norvegicus (Rat)

GLP1R Proteins for Mus musculus (Mouse)

GLP1R Proteins for Homo sapiens (Human)

GLP1R Proteins for Homo sapiens(Human)

GLP1R ELISA Kit

GLP1R ELISA Kit for Mus musculus (Mouse)



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