在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NOL3 Antibody

NOL3 Antibody

  • 中文名稱：
    NOL3兔多克隆抗體
  • 貨號：
    CSB-PA034483
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA034483(NOL3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA034483(NOL3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NOL3
  • 別名：
    Apoptosis repressor with CARD antibody; ARC antibody; Muscle enriched cytoplasmic protein antibody; Muscle-enriched cytoplasmic protein antibody; MYC antibody; MYP antibody; Nol3 antibody; NOL3_HUMAN antibody; NOP antibody; Nop30 antibody; Nucleolar protein 3 (apoptosis repressor with CARD domain) antibody; Nucleolar protein 3 antibody; Nucleolar protein of 30 kDa antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human NOL3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in RNA splicing.; Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors. Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis. Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation. Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner. Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I. Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia. Inhibits too myoblast differentiation through caspase inhibition.
  • 基因功能參考文獻：
    1. Results show that in response to DNA damage, p53 total levels increase proportionally to the strength of the damage; however, p53 tetramers are formed at a constant rate under the control of ARC protein. PMID: 25344068
    2. role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma PMID: 28464919
    3. a novel genetic primary myelofibrosis-like mouse model and identify a tumor suppressor role for NOL3 in the pathogenesis of myeloid malignancies. PMID: 28232469
    4. Increased ARC expression is associated with liver metastasis of colorectal cancer. PMID: 26721253
    5. RUNX3, miR-185 and ARC regulate the sensitivity of gastric cancer cells to chemotherapy. PMID: 24763054
    6. ARC is regulated via BIRC2/MAP3K14 signalling and its overexpression in AML or MSCs can function as a resistant factor to birinapant-induced leukaemia cell death. PMID: 25079338
    7. high expression of ARC plays an important role in the pathogenesis of nasopharyngeal carcinoma and leads to X-radiation and cisplatin resistance in nasopharyngeal carcinoma. PMID: 23877130
    8. ARC is a previously unrecognized inhibitor of apoptosis in beta-cells and that its protective effects are mediated through suppression of the ER stress response pathway. PMID: 22933109
    9. This study utilized unbiased, genome-wide approaches to identify a NOL3 mutation that likely causes Familial cortical myoclonus. PMID: 22926851
    10. HIF-1alpha directly bound to hypoxia-responsive element located at -419 to -414 of ARC gene, which is essential for HIF-1-induced expression. PMID: 22475487
    11. Data show that ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells. PMID: 22037876
    12. ARC, previously unlinked to pulmonary hypertension, is a critical determinant of vascular remodeling in this syndrome. PMID: 22082675
    13. Results suggest that ARC expression levels are highly prognostic in AML and that ARC is a potential therapeutic target in AML. PMID: 21041716
    14. Ras induces ARC in epithelial cancers, and ARC plays a role in the oncogenic actions of Ras PMID: 20392691
    15. These results suggest that the antiapoptotic effect of apoptotic repressor with caspase recruitment domain is, in part, due to inhibition of voltage-gated potassium channels in cardiomyocytes. PMID: 12734105
    16. calcium binding mediates regulation of caspase 8 and cell death by ARC PMID: 15509781
    17. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells PMID: 15848180
    18. ARC was present in the cytoplasm and nuclei of epithelial cells in invasive ductal carcinoma PMID: 15861191
    19. is downregulated in human failing myocardium PMID: 16505176
    20. nuclear apoptosis repressor with caspase recruitment domain (ARC)is induced in cancer cells and negatively regulates p53 PMID: 18087040
    21. the high level of ARC protein and the constitutive phosphorylation of ARC in cancer cells may play an important role in the protection of cancer cells against oxidative stress PMID: 18172857
    22. Transfection of cDNA encoding ARC into Me1007 cells inhibited both caspase-8 activation and apoptosis induced by thapsigargin or tunicamycin. PMID: 18245485
    23. ARC is a novel marker of human colon cancer and suggest that it may be a general feature of epithelial cancers. PMID: 18469522
    24. the balance between antiapoptotic ARC and proapoptotic caspase-8 is the only one to be disturbed during carcinogenesis and tumour progression of renal cell carcinomas PMID: 18516683
    25. ARC undergoes poly-ubiquitination and subsequent proteasome-dependent degradation. Mutation of ARC's lysine residues prevents this and enhances its pro-survival effects. PMID: 17142452
    26. ARC holds multiple death pathways in check by non-homotypic death-fold interactions. Loss of ARC disinhibits these, leading to accelerated DISC assembly and Bax activation and may be an apoptotic trigger in heart failure and ischemia-reperfusion. PMID: 15383280
    27. The CARD of ARC binds the Bax C-terminus, preventing Bax activation and activation of the intrinsic mitochondrial pathway PMID: 15383280
    28. ARC is recruited to the Fas DISC. By interacting with Fas and FADD through CARD-DD and CARD-DED interactions, ARC prevents DISC assembly and procaspase-8 activation. PMID: 15383280

    顯示更多

    收起更多

  • 相關疾病：
    Myoclonus, familial cortical (FCM)
  • 亞細胞定位：
    [Isoform 1]: Nucleus, nucleolus.; [Isoform 3]: Cytoplasm.; [Isoform 2]: Cytoplasm. Mitochondrion. Sarcoplasmic reticulum. Membrane; Lipid-anchor.
  • 組織特異性：
    Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 7869

    OMIM: 605235

    KEGG: hsa:8996

    STRING: 9606.ENSP00000268605

    UniGene: Hs.513667



主站蜘蛛池模板： 亚洲欧美国产双大乳头| 亚洲精品国产一区二区精华液| 国产精品va在线观看无码| 尤物av无码色av无码| 精品亚洲一区二区三区在线播放| 天堂网www天堂在线资源| 亚洲a∨精品永久无码| 50岁熟妇的呻吟声对白| 免费观看性欧美大片无片| 国产成人精品综合久久久| 美女啪啪网站又黄又免费| 婷婷五月俺也去人妻| 人人妻人人超人人| 亚洲丰满熟女一区二区v| 少妇真实被内射视频三四区| 欧美色就是色| 黄网站免费永久在线观看下载| 天堂а√在线地址8| 51久久国产露脸精品国产| 老牛精品亚洲成av人片| 精品久久久久久国产潘金莲| 无人区乱码区1卡2卡三卡网站 | 久久精品麻豆日日躁夜夜躁| 中国熟妇牲交视频| 欧美高潮喷水大叫| 激情国产一区二区三区四区| 综合网日日天干夜夜久久| 区二区三区玖玖玖| 日本少妇浓毛bbwbbwbbw| 五月婷婷久久草丁香| 日本高清www午色夜com| 人人做人人爽久久久精品| 人妻丰满熟妇ⅴ无码区a片| 午夜免费啪视频| 久久综合一色综合久久小蛇| 久久人人爽人人爽爽久久小说| 777亚洲精品乱码久久久久久| 国产97色在线 | 免费| 国产毛片一区二区精品| 狠狠色丁香久久综合婷婷| 中文字幕无码人妻aaa片|