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  4. CLPB Antibody

CLPB Antibody

  • 中文名稱：
    CLPB兔多克隆抗體
  • 貨號：
    CSB-PA884428LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: CLPB antibody at 5μg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 79, 76, 73, 75, 58 kDa
      Observed band size: 79 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA884428LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    Rabbits were immunized to generate the CLPB polyclonal antibody, which is specifically designed to recognize and bind to the human CLPB protein. The development of this antibody involved using a recombinant human CLPB protein that consisted of amino acids 1-350 as an immunogen. The resulting CLPB antibody was then purified using protein G affinity chromatography, achieving a purity level of up to 95%.

    This antibody only reacts with human samples. It has been extensively tested in various experimental settings, such as ELISA, WB, and IHC, to investigate the expression, localization, and activity of the CLPB protein in different contexts. These tests have demonstrated the ability of the CLPB polyclonal antibody to effectively identify and detect the CLPB protein in various experimental conditions.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CLPB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLPB
  • 別名：
    Caseinolytic peptidase B antibody; Caseinolytic peptidase B protein homolog antibody; clpB antibody; ClpB caseinolytic peptidase B homolog (E. coli) antibody; ClpB caseinolytic peptidase B homolog antibody; CLPB_HUMAN antibody; FLJ13152 antibody; HSP78 antibody; SKD3 antibody; Suppressor of potassium transport defect 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Caseinolytic peptidase B protein homolog protein (1-350AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CLPB Antibody (CSB-PA884428LA01HU)，的標記方式是Non-conjugated。對于CLPB Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA884428LB01HU CLPB Antibody, HRP conjugated ELISA
    FITC CSB-PA884428LC01HU CLPB Antibody, FITC conjugated
    Biotin CSB-PA884428LD01HU CLPB Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6.
  • 基因功能參考文獻：
    1. The neonatal presentation of CLPB deficiency predicts the course of disease in later life, which is extremely important for counselling. PMID: 28687938
    2. Case Reports: bi-allelic CLPB mutations cause cataract, renal cysts, nephrocalcinosis and 3-methylglutaconic aciduria, a novel disorder of mitochondrial protein disaggregation. PMID: 25595726
    3. Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria PMID: 25650066
    4. ClpB can passively thread soluble denatured proteins. PMID: 25288401
    5. Mutations in CLPB define a syndrome with intellectual disability, congenital neutropenia, progressive brain atrophy, movement disorder, cataracts, and 3-methylglutaconic aciduria. PMID: 25597510
    6. CLPB is proposed to function as a mitochondrial chaperone involved in disaggregation of misfolded proteins, resulting from stress such as heat denaturation. PMID: 25597511
    7. ClpB-DnaK reactivated all aggregated fusion proteins with similar efficiency, without unfolding native domains, demonstrating that partial threading of the misfolded moiety is sufficient to solubilize aggregates. PMID: 18488042
    8. formation of the DnaK-ClpB bichaperone network is a three step process PMID: 19698713

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  • 相關疾病：
    3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia (MEGCANN)
  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    ClpA/ClpB family
  • 組織特異性：
    Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes.
  • 數據庫鏈接：

    HGNC: 30664

    OMIM: 616254

    KEGG: hsa:81570

    STRING: 9606.ENSP00000294053

    UniGene: Hs.523877



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