在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BOK Antibody

BOK Antibody

  • 中文名稱：
    BOK兔多克隆抗體
  • 貨號(hào)：
    CSB-PA437965
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA437965(BOK(BH3 domain) Antibody) at dilution 1/20, on the right is treated with synthetic peptide.
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA437965(BOK(BH3 domain) Antibody) at dilution 1/20, on the right is treated with synthetic peptide.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    BOK
  • 別名：
    Bcl 2 related ovarian killer protein antibody; Bcl-2-like protein 9 antibody; Bcl-2-related ovarian killer protein antibody; BCL2 related ovarian killer antibody; Bcl2-L-9 antibody; BCL2L9 antibody; BOK antibody; BOK_HUMAN antibody; BOKL antibody; Hbok antibody; MGC4631 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human BOK(BH3 domain)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:20-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner. In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response. Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release. In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation. Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation. In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1.; Pro-apoptotic molecule exerting its function through the mitochondrial pathway.
  • 基因功能參考文獻(xiàn)：
    1. Loss of BOK is associated with non-small-cell lung carcinoma. PMID: 28744854
    2. Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40) homolog, subfamily B, member 12) PMID: 28536268
    3. Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT) but is not affected by its antisense transcript. PMID: 24806027
    4. First evidence for a key role of the BOK-MCL1 system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 balance toward the build-up of isoforms that triggers placental autophagy. PMID: 24113155
    5. Bok may govern IP3R cleavage and activity during apoptosis. PMID: 23884412
    6. Data conclude that Mtd-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd found in PE may contribute to increased trophoblast proliferation. PMID: 19942931
    7. BOK and NOXA are essential mediators of p53-dependent apoptosis PMID: 15102863
    8. A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia. PMID: 15775999
    9. Studies showed that hBok was distributed in both the cytosol and intracellular membranes of healthy cells. PMID: 15868100
    10. a link between the apoptotic activity and nuclear localization of a pro-apoptotic Bok PMID: 16302269
    11. Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family PMID: 16772296
    12. BOKAS is a natural antisense transcript that regulates the pro-apoptotic activity of human Bok PMID: 19287972

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Membrane.; [Isoform 2]: Membrane. Cytoplasm.
  • 蛋白家族：
    Bcl-2 family
  • 組織特異性：
    Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in s
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1087

    OMIM: 605404

    KEGG: hsa:666

    STRING: 9606.ENSP00000314132

    UniGene: Hs.293753



主站蜘蛛池模板： 起碰免费公开97在线视频| av人摸人人人澡人人超碰手机版| 伊人久久大香线蕉无码不卡| 人与嘼av免费| 亚洲综合一区二区三区无码| 精品人妻少妇一区二区三区在线| 国产福利在线视频蜜芽tv| 色一情一乱一乱一区99av| 天堂资源在线www在线观看| 色偷偷色噜噜狠狠网站久久| 天堂а√在线中文在线| 欧美亚洲日韩国产综合电影| 国产精品夜夜春夜夜爽久久| 日产精品一二三区| 东京热无码av一区二区| 内射干少妇亚洲69xxx| 韩国无码av片在线观看| 欧美日韩国产专区一区二区| 成人毛片18女人毛片免费| 国产精品免费精品自在线观看| 三上悠亚精品一区二区久久 | 久久www免费人成精品| 2020精品自拍视频曝光| 无码专区手机在线播放| 国产无遮挡又黄又爽高潮| 中文字幕乱码中文乱码777| 国产香蕉尹人在线视频你懂的 | 免费的av网站手机版| 色综合中文综合网| 久久精品国产精品久久久| 真人啪啪高潮喷水呻吟无遮挡| 中文字幕av无码一区二区三区电影| 国产成人无码aⅴ片在线观看 | 日韩超碰人人爽人人做人人添| 色老头av亚洲一区二区男男| 亚洲精品无码专区在线播放| 88国产精品视频一区二区三区| 亚洲综合国产一区二区三区| 国产国拍亚洲精品av| 人体内射精一区二区三区| 久久精品亚洲日本波多野结衣|