在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-RPS6KA5 (Ser212) Antibody

Phospho-RPS6KA5 (Ser212) Antibody

  • 中文名稱：
    磷酸化-RPS6KA5 (Ser212)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA997224
  • 規(guī)格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from NIH-3T3 cells treated with EGF using MSK1 (Phospho-Ser212) antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RPS6KA5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 212 (A-Y-S(p)-F-C) derived from Human MSK1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury. Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity.
  • 基因功能參考文獻(xiàn)：
    1. MSK1 was overexpressed in 148 out of 329 colorectal cancer (CRC) patients. CRC patients with high MSK1 expression had shorter overall survival than those with low MSK1, especially among patients with stage III tumors. Overexpression of MSK1 is associated with poor prognosis in CRC and is connected to tumor aggressiveness. PMID: 28314603
    2. High MSK1 is associated with improved breast cancer-specific survival in early stage invasive breast cancer patients, and has additional prognostic value in HER2-negative and non-basal like disease. PMID: 29327245
    3. Our findings indicate that MSK1/beta-catenin signaling serves as an escape survival signal upon PI3K inhibition and provides a strong rationale for the combined use of PI3K and MSK1/beta-catenin inhibition to induce lethal growth inhibition in human GBM cells. PMID: 27196759
    4. Results show that MSK1 phosphorylates H3S10 through p38-MAPK pathway in gastric cancer patients. PMID: 27588146
    5. Interrupting MSK1 activation is a new target for antioxidants. PMID: 26030901
    6. Increased MSK1 activity is critically important for Epstein-Barr virus LMP1-promoted cell proliferation and transformation. PMID: 25958199
    7. Authors conclude that paramyxoviruses trigger the DNA damage response, a pathway required for MSK1 activation of phospho Ser 276 RelA formation to trigger the IRF7-RIG-I amplification loop necessary for mucosal interferon production. PMID: 25520509
    8. These results highlight the relevance of MSK1 in the up-regulation of RARbeta by prostaglandin E2. PMID: 24953041
    9. MSK1 plays an important role for hormone-dependent breast cancer growth PMID: 23604116
    10. Angiopoietin 2-mediated signaling via survivin/ref-1/MSK-1 pathway promotes doxorubicin resistance in HepG2 cells. PMID: 23643942
    11. Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner PMID: 22626465
    12. MSK1 is an important downstream kinase involved in CS-induced NF-kappaB activation PMID: 22312446
    13. MSK1 is a direct and potent transcriptional activator when targeted to c-fos promotor, and when targeted to alpha-globin promoter induces H3 S28 phosphorylation reactivating expression of this polycomb-silenced gene. PMID: 21282660
    14. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. PMID: 20408143
    15. MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression PMID: 20406806
    16. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. PMID: 20198339
    17. The MSK1 can be phosphorylated and activated in cells by both ERK1/2 and p38alpha. PMID: 20044958
    18. Data provide evidence that p38 Map kinase pathway is activated leading to increased upregulation of mixed lineage kinase 3, MKK3/6, MSK1, and Mapkapk2, upon treatment of BCR/ABL expressing cells with dasatinib. PMID: 19672773
    19. IL1beta and TNFalpha activation of MSK1 and CREB and cAMP-response element signaling cascades occurs via ERK/p38 MAP kinases and are crucial aspects of the intracellular mechanisms that mediate MUC5AC gene expression PMID: 12690113
    20. acetylation of histones may stimulate transcription by suppressing an inhibitory phosphorylation by MSK1 PMID: 15010469
    21. MSK1 has a role in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways PMID: 15133024
    22. essential role of the C-terminal domain of MSK1 for its constitutive interaction with group V secretory phospholipase A(2), which appears essential to support VEGF-mediated PAF synthesis PMID: 16479592
    23. Plays a positive role in the control of cell proliferation of both HaCaT keratinocytes and the A431 human epidermoid carcinoma line. PMID: 16532028
    24. As MSK1 regulates the production of pro-inflammatory cytokines, it may play a role in the pathogenesis of psoriasis. PMID: 16543895
    25. MSK1 has a role downstream of p38 in the regulation of As2O3 responses PMID: 16762916
    26. Thr700 phosphorylation relieves the inhibition of MSK1 by a C-terminal autoinhibitory helix and helps induce a conformational shift that protects Thr581 from dephosphorylation PMID: 17117922
    27. the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1-dependent phosphorylation of p65/RelA(Ser(276)) PMID: 18424438
    28. This study provides therefore a direct link between MSK1-mediated phosphorylation of Ser276 p65 of NF-kappaB, allowing its binding to the SCF intronic enhancer, and pathophysiological SCF expression in inflammation. PMID: 19197368
    29. IL-17F may be involved in airway inflammation and remodeling via the induction of IL-11, and RafI-MEK1/2-ERK1/2-MSK1-CREB is identified as a novel signaling pathway. PMID: 19251839
    30. Data reveal that TPA activates transcription of TBX2 through activating MSK1, which leads to an increase in phosphorylated histone H3 and the recruitment of Sp1 to the TBX2 gene. PMID: 19633291
    31. We conclude that RSV induces RelA activation in the innate inflammatory response via a pathway separate from that controlling RelA cytoplasmic release, mediated by ROS signaling to cytoplasmic MSK1 activation and RelA Ser-276 phosphorylation. PMID: 19706715

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 組織特異性：
    Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10434

    OMIM: 603607

    KEGG: hsa:9252

    STRING: 9606.ENSP00000261991

    UniGene: Hs.510225



主站蜘蛛池模板： 无码人妻精品一区二区三| 99re6热精品视频在线观看| 米奇影视第四色| 男女又色又爽又爽视频| 免费无人区男男码卡二卡| 亚洲精品无码成人片| 先锋影音av最新资源| 三级男人添奶爽爽爽视频| 中文精品久久久久人妻不卡| 男男啪啪激烈高潮cc漫画免费| 妺妺窝人体色www在线小说| 久久精品成人无码观看不卡| 护士张开腿被奷日出白浆| 国产在线精品一品二区| 樱桃视频影视在线观看免费| 亚洲国产av高清无码| 人妻丰满熟妇无码区免费| 中文字日产乱码免费1～3软件 | 少妇高潮一区二区三区99| 久久久精品人妻一区亚美研究所| 国产亚洲视频在线播放香蕉| 国产精品毛片av999999| 在线а√天堂中文官网| 欧美人妻aⅴ中文字幕| 又污又爽又黄的网站| 天堂网www在线资源最新版| 啪一啪射一射插一插| 国产精品久久无码一区| 亚洲精品成人片在线观看精品字幕| 亚洲色一色噜一噜噜噜| 亚洲色大成影网站www永久| 两个黑人大战嫩白金发美女| 日本欧美大码a在线观看| 国产成人亚洲综合青青| 婷婷色五月开心五月| 性一交一黄一片| 女人高潮流白浆视频| 无码人妻aⅴ一区二区三区玉蒲团| 青草草97久热精品视频| 日本污ww视频网站| 中文乱码字慕人妻熟女人妻|