在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Eukaryotic translation initiation factor 4H (EIF4H)

  • 中文名稱:
    人EIF4H重組蛋白
  • 貨號:
    CSB-YP007571HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人EIF4H重組蛋白
  • 貨號:
    CSB-EP007571HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人EIF4H重組蛋白
  • 貨號:
    CSB-EP007571HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人EIF4H重組蛋白
  • 貨號:
    CSB-BP007571HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人EIF4H重組蛋白
  • 貨號:
    CSB-MP007571HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF 4H; eIF-4H; EIF4H; Eukaryotic translation initiation factor 4H; IF4H_HUMAN; KIAA0038 ; WBSCR1; Williams Beuren syndrome chromosomal region 1 protein homolog ; Williams Beuren syndrome chromosome region 1; Williams-Beuren syndrome chromosomal region 1 protein; Williams-Beuren syndrome chromosome region 1; WSCR1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-248
  • 氨基酸序列
    ADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能:
    Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
  • 基因功能參考文獻:
    1. The results from these procedures revealed eIF4H to be one of the targets of miR-519d. Downregulated eIF4H was analogous to the overexpressed miR-519d obtained from miR-519d agomir and si-eIF4H transfection. In summary, it can be concluded that miR-519d targets eIF4H in lung adenocarcinoma to inhibit cell proliferation and invasion PMID: 28351305
    2. Results demonstrate that eukaryotic translation initiation factor 4H (eIF4H) plays a crucial role in translational control. PMID: 26498689
    3. Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-kappaB. PMID: 23776612
    4. Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR. PMID: 21427765
    5. results suggest that eIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy PMID: 20473909
    6. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    7. eIF4H binding is required for herpes simplex virus virion host shutoff-induced degradation of many mRNAs, perhaps by targeting Vhs to mRNAs and to preferred sites within mRNAs. PMID: 18448541
    8. The interaction of eIF4AI with two accessory factors, eIF4B and eIF4H, was studied. PMID: 18719248
    9. Study reports the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. PMID: 19203580
    10. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

    顯示更多

    收起更多

  • 相關疾病:
    EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 組織特異性:
    The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
  • 數據庫鏈接:

    HGNC: 12741

    OMIM: 603431

    KEGG: hsa:7458

    STRING: 9606.ENSP00000265753

    UniGene: Hs.520943



主站蜘蛛池模板: 宝贝腿开大点我添添公视频免费| 国产成人涩涩涩视频在线观看| 欧美人与动另类xxxx| 亚洲国产精品久久一线不卡| 日韩精品无码一区二区三区| 亚洲欧美日韩综合久久久| 免费无码av片在线观看潮喷| 1区2区3区高清视频| 国产欧美综合在线观看第十页 | 久在线视视频在线观看| 99久久久无码国产精品免费砚床| 久久不见久久见免费影院www| 日本精品少妇一区二区三区| 无遮挡aaaaa大片免费看| 日本熟妇色一本在线观看| 99re久久热在这里精品| 精品一区二区三区在线播放视频 | 亚洲中文无码永久免| 色婷婷五月综合色啪网| 激情无码人妻又粗又大| 国内老熟妇对白hdxxxx| 人人鲁人人莫人人爱精品| 亚洲欧洲无码av不卡在线| 欧美精品v欧洲精品| 国产精品无码一本二本三本色| 人妻色综合网站| 国产真实伦对白全集| 欧美性狂猛xxxxx深喉| 国产美女精品视频线免费播放软件| 日产精品久久久久久久性色| 国产乱子伦一区二区三区| 丝袜无码一区二区三区| 国产农村毛卡片| 亚洲国产香蕉碰碰人人| 国产免费久久精品99久久| 亚洲红杏成在人线免费视频| 国产精品真实灌醉女在线播放| 2020国产在线拍揄自揄视频| 大地资源网中文第五页| av无码中文一区二区三区四区| 老男人久久青草av高清|