在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA polymerase delta subunit 4 (POLD4)

  • 中文名稱:
    人POLD4重組蛋白
  • 貨號:
    CSB-YP862074HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人POLD4重組蛋白
  • 貨號:
    CSB-EP862074HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人POLD4重組蛋白
  • 貨號:
    CSB-EP862074HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人POLD4重組蛋白
  • 貨號:
    CSB-BP862074HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人POLD4重組蛋白
  • 貨號:
    CSB-MP862074HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    POLD4; POLDSDNA polymerase delta subunit 4; DNA polymerase delta subunit p12
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-107
  • 氨基酸序列
    MGRKRLITDS YPVVKRREGP AGHSKGELAP ELGEEPQPRD EEEAELELLR QFDLAWQYGP CTGITRLQRW CRAKQMGLEP PPEVWQVLKT HPGDPRFQCS LWHLYPL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
  • 基因功能參考文獻:
    1. the p12/Pol delta is a target as a nuclear substrate of mu-calpain in a calcium-triggered apoptosis and appears to be a potential marker in the study of the chemotherapy of cancer therapies. PMID: 24691096
    2. A parallel study of Pol delta4 and Pol delta3 in Okazaki fragment processing provides evidence for a role of Pol delta3 in DNA replication PMID: 24300032
    3. Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells. PMID: 24035200
    4. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression. PMID: 24022480
    5. Data indicate that CRL4(Cdt2) regulates the degradation of the p12 subunit of Pol delta4. PMID: 23913683
    6. The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways. PMID: 23233665
    7. Low POLD4 is associated with lung cancer. PMID: 20861182
    8. these results indicate that POLD4 is required for the in vitro pol delta activity, and that it functions in cell proliferation and maintenance of genomic stability of human cells. PMID: 19931513
    9. pol delta interacts with PCNA via at least two of its subunits, and p12 could play a role in stabilizing the overall pol delta-PCNA complex as well as pol delta itself PMID: 16510448
    10. The DNA polymerase delta enzyme, as well as the isolated p12 subunit, stimulates the DNA helicase activity of Bloom's syndrome helicase. PMID: 18682526

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    DNA polymerase delta subunit 4 family
  • 數據庫鏈接:

    HGNC: 14106

    OMIM: 611525

    KEGG: hsa:57804

    STRING: 9606.ENSP00000311368

    UniGene: Hs.523829



主站蜘蛛池模板: 久久99er6热线精品首页| 少妇人妻偷人激情视频| 国产无套粉嫩白浆在线观看| 肥臀熟女一区二区三区| 99re6在线视频精品免费下载| 人妻少妇heyzo无码专区 | 麻豆精产一二三产区| 国产精品久久人妻无码网站蜜臀| 亚洲国产成人精品激情姿源| 亚洲线精品一区二区三区影音先锋| 国产精品久久久久久久久免费| 欧美精品国产aⅴ一区二区在线| 2018年亚洲欧美在线v| 国内精品久久人妻无码网站| 欧洲国产精品无码专区影院| 国产伦久视频免费观看视频| 国精品人妻无码一区二区三区喝尿| 真人做作爱视频| 中国精品无码免费专区午夜| 色欲综合久久躁天天躁| 色偷偷亚洲男人本色| 日本丰满熟妇videossex一| 丰满日韩放荡少妇无码视频| 18禁无遮挡无码国产免费网站| 18禁超污无遮挡无码免费游戏| 一本一本久久a久久精品综合| 亚洲国产欧美在线成人| 亚洲欧美综合精品成人网| 国产成人a无码短视频| 国产呻吟久久久久久久92| 日本中国内射bbxx| 人妻少妇精品专区性色av| 亚洲精品第一国产综合国服瑶| 牲交欧美兽交欧美| 免费超爽大片黄| 强制高潮18xxxx按摩| 国产成人精品s8视频| 国产精品v欧美精品v日韩精品| 国产精品一卡二卡三卡| 伊人婷婷色香五月综合缴缴情| 日日碰狠狠添天天爽五月婷|