在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDK3 Antibody

  • 中文名稱:
    CDK3兔多克隆抗體
  • 貨號:
    CSB-PA005064GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CDK3
  • 別名:
    Cdk 3 antibody; Cdk3 antibody; CDK3_HUMAN antibody; CDKN3 antibody; Cell division kinase 3 antibody; Cell division protein kinase 3 antibody; Cyclin dependent kinase 3 antibody; Cyclin-dependent kinase 3 antibody; OTTHUMP00000206828 antibody; p36 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human CDK3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
  • 基因功能參考文獻:
    1. These results suggest that miR-125a-3p can function as a novel tumor suppressor in ER(+) breast cancer by targeting CDK3, which may be a potential therapeutic approach for TamR breast cancer therapy PMID: 28939591
    2. HuR facilitated lung cancer stemness dependent on CDK3 expression. miR-873 or miR-125a-3p level was negatively correlated with HuR and CDK3 expression levels in lung cancer tissues. HuR facilitates lung cancer stemness via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis. PMID: 29344850
    3. ectopic expression of HuR promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 mRNA. PMID: 28501005
    4. These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis. PMID: 27893713
    5. The analysis of tumor and matched normal lung tissues indicates that miR-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR-150 transfection experiments with cancer-derived cell lines reveal that miR-150-mediated CDK3 suppression directly induces growth inhibition. PMID: 28108217
    6. High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. PMID: 26755651
    7. Data indicate that microRNA miR-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC) through inhibition of E2F2 transcription factor (E2F2), cyclin-dependent kinases CDK3 and CDK6. PMID: 26498144
    8. Mir-873 inhibits ESR1 activity and cell growth via targeting CDK3. PMID: 25531331
    9. CDK3 is associated with the progression of NPC, and may be a potential biomarker for prediction of the prognosis of patients with NPC. PMID: 24691537
    10. The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3. PMID: 21067790
    11. A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently. PMID: 15084261
    12. Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1. PMID: 18794154

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in cancer cell lines and glioblastoma tissue.
  • 數據庫鏈接:

    HGNC: 1772

    OMIM: 123828

    KEGG: hsa:1018

    STRING: 9606.ENSP00000400088

    UniGene: Hs.706766



主站蜘蛛池模板: av在线无码专区一区| 精品日本免费一区二区三区| 在线无码av一区二区三区| 免费无码又爽又黄又刺激网站| 乱中年女人伦| 中文天堂在线www| 成人亚洲欧美在线观看| 国产美女裸体丝袜喷水视频| 成人免费午夜无码视频| 一本大道东京热无码一区| 国产精品久久久久久| 中文字幕av久久激情亚洲精品| 乱子伦国产对白在线播放| 亚洲人成网亚洲欧洲无码| 亚洲视频在线观看| 亚洲中文字幕婷婷在线| 亚洲精品久久久久久久久久久捆绑 | 成人国产精品一区二区免费看| 国产96在线 | 亚洲| 伊人激情av一区二区三区| 伊人久久大香线蕉av最新| 精品人妻伦一二三区久久aaa片| 亚洲国产三级在线观看| 四川少妇大战4黑人| 硬了进去湿好大娇喘视频| 高清乱码一区二区三区| 欧美浓毛大泬视频| 国产精品日日做人人爱| 影音先锋人妻每日资源站| 中文字幕aⅴ在线视频| 午夜无码一区二区三区在线观看 | 久久中文字幕无码中文字幕有码| 免费国产午夜视频在线| 无码国产69精品久久久久孕妇| 精品国内自产拍在线播放观看| 国产成人无码视频网站在线观看| 亚洲一区二区三区四区五区六| 精品国产不卡一区二区三区 | 国产精品高清不卡在线播放| 亚洲色爱免费观看视频| 狠狠cao日日穞夜夜穞av|