在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-YP858742MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-EP858742MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-BP858742MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rap1b重組蛋白
  • 貨號：
    CSB-MP858742MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rap1b; Ras-related protein Rap-1b; GTP-binding protein smg p21B
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-181
  • 氨基酸序列
    MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
  • 基因功能參考文獻：
    1. findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process. PMID: 26844834
    2. Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions. PMID: 25092872
    3. Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone. PMID: 24790136
    4. two different activation mechanisms of Rap1b as well as novel functions of Rap1b in platelet secretion and in integrin alpha(IIb)beta(3) outside-in signaling. PMID: 21940635
    5. Rap1b-dependent VEGF-VEGFR2 activation is in part mediated via integrin alpha(v)beta(3). PMID: 21636859
    6. Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. PMID: 20733035
    7. Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal PMID: 15331589
    8. Data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target. PMID: 15696195
    9. These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells. PMID: 17993608
    10. Rap1b-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. PMID: 18305243
    11. Rap1b-deficient B cells had impaired adhesion and reduced chemotaxis in vitro, and lessened homing to lymph nodes in vivo PMID: 18319399
    12. Rap1b is the dominant isoform in B cells and regulates cell proliferation, cell adhesion, T-dependent humoral responses, cell migration in B cells. PMID: 18714009
    13. Rap1b ameliorates glucose-induced mitochondrial dysfunction in renal tubular cells PMID: 18753253
    14. Rap1b is required for maximal GPVI-induced but not ADP-induced activation of alpha2beta1 in murine platelets. PMID: 19192113

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cytoplasm, cytosol. Cell junction.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數據庫鏈接：


主站蜘蛛池模板： 少妇久久久久久被弄到高潮| av大片在线无码免费| 韩国v欧美v亚洲v日本v| 亚洲精品久久无码av片| 狠狠色噜噜狠狠色综合久| 9l国产精品久久久久麻豆| 亚洲一区二区三区无码影院| 久久精品第九区免费观看| а天堂中文最新一区二区三区| 无码av大香线蕉| 青青国产揄拍视频| 东京热无码一区二区三区av| 最近最新中文字幕高清免费| 欧美熟妇另类久久久久久不卡| 亚洲另类无码专区国内精品| 久久久精品456亚洲影院| 韩国主播av福利一区二区| 久久久久久亚洲精品| 久久久久久久女国产乱让韩| 久久精品网站免费观看| 日本无码人妻一区二区色欲| 40岁成熟女人牲交片20分钟| 久99久无码精品视频免费播放| 成人毛片av免费| 欧洲精品一线二线三线区别| 日韩人妻一区二区三区免费| 亚洲精品福利一区二区三区蜜桃| 日本国产一区二区三区在线观看| 狠狠色丁香久久综合婷婷| 日日噜噜噜夜夜爽爽狠狠| 国产有奶水哺乳期无码avav| 国产欧美日韩亚洲18禁在线| 女人被强╳到高潮喷水在线观看| 久久综合色鬼综合色| 亚洲国产精品成人综合色| 男女无遮挡xx00动态图120秒| 国产精品久久久久久无码| 国产视频亚洲精品视频| 狠狠色狠狠色综合日日五| 国产精品99久久免费黑人人妻| 新版资源天堂中文|