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  4. Recombinant Human Zinc fingers and homeoboxes protein 1 (ZHX1), partial

Recombinant Human Zinc fingers and homeoboxes protein 1 (ZHX1), partial

  • 中文名稱：
    人ZHX1重組蛋白
  • 貨號：
    CSB-YP891955HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZHX1重組蛋白
  • 貨號：
    CSB-EP891955HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZHX1重組蛋白
  • 貨號：
    CSB-EP891955HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZHX1重組蛋白
  • 貨號：
    CSB-BP891955HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZHX1重組蛋白
  • 貨號：
    CSB-MP891955HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZHX1
  • Uniprot No.：
  • 別名：
    ZHX 1; ZHX1; ZHX1_HUMAN; Zinc finger and homeodomain protein 1; Zinc fingers and homeobox 1; Zinc fingers and homeoboxes 1; Zinc fingers and homeoboxes protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.
  • 基因功能參考文獻：
    1. ZHX1 expression is correlated with renal cell carcinoma progression and poor survival. PMID: 28152006
    2. ZHX1 was found to play essential roles in the proliferation, migration, and invasion of cholangiocarcinoma cells, and its effect on the proliferation was mediated partially through EGR1. PMID: 27835650
    3. together, this study demonstrates that ZHX1 plays crucial roles in the progression of glioblastoma, and its findings suggest that ZHX1 be viewed as a potential prognostic maker and therapeutic target of glioblastoma. PMID: 28351300
    4. miR-199a-3p may function as a novel tumor promoter in gastric cancer and its oncogenic activity may involve the direct targeting and inhibition of ZHX1 PMID: 25448600
    5. Low expression of ZHX1 may be responsible for hepatocarcinogenesis. PMID: 24064680
    6. Study showed that ZHX1 is SUMOylated by Ubc9 with SUMO1 at the sites K159, K454, and K626 and that the SUMOylation of ZHX1 regulated the stability, ubiquitination and transcriptional activity of ZHX1. PMID: 23686912
    7. This study characterized features of ZHX-1 involved in nuclear localization, dimerization, and transcriptional activity, and mapped these domains. PMID: 12237128
    8. a search of ZHX1-interacting proteins using a yeast two-hybrid system PMID: 12659632
    9. ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease PMID: 17056598
    10. ZHX1 enhanced the transcriptional repression mediated by DNMT3B when DNMT3B is directly targeted to DNA. These results showed for the first the direct linkage between DNMT and zinc-fingers homeoboxes protein, leading to enhanced gene silencing by DNMT3B PMID: 17303076
    11. structure of the tandem zinc-finger region of human ZHX1 PMID: 19348505

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  • 亞細胞定位：
    Nucleus. Note=Colocalized in the nucleus with DNMT3B.
  • 蛋白家族：
    ZHX family
  • 組織特異性：
    Ubiquitously expressed. Expressed in podocytes.
  • 數據庫鏈接：

    HGNC: 12871

    OMIM: 604764

    KEGG: hsa:11244

    STRING: 9606.ENSP00000297857

    UniGene: Hs.521800



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