在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SYCP3 Antibody

  • 中文名稱:
    SYCP3兔多克隆抗體
  • 貨號:
    CSB-PA362770
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA362770(SYCP3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, human seminoma tissue, human liver cancer tissue, Primary antibody: CSB-PA362770(SYCP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    choline phosphotransferase 1 antibody; chpt1 antibody; COR 1 antibody; COR1 antibody; MGC71888 antibody; RNASCP3 antibody; SCP 3 antibody; SCP-3 antibody; SCP3 antibody; SPGF4 antibody; Sycp 3 antibody; Sycp3 antibody; SYCP3_HUMAN antibody; Synaptonemal complex protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SYCP3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
  • 基因功能參考文獻:
    1. SCP3 is associated with lymphangiogenesis and provides insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy strategy. PMID: 28623914
    2. In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure. PMID: 28287952
    3. SYCP3 binds to RAD51 and attenuates RAD51 activity during meiosis. PMID: 28745000
    4. SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation PMID: 24950965
    5. The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human. PMID: 25059562
    6. SCP3 plays an important role in the progression of cervical cancer PMID: 24905095
    7. SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population PMID: 22670862
    8. screening for genetic variants in AURKB and SYCP3 among these patients with reproductive problems using Sanger sequencing. Only one apparently non-pathogenic deletion was found in SYCP3. PMID: 23100464
    9. Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival. PMID: 23069255
    10. mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction. PMID: 22197129
    11. Expression of SYCP3 inhibits the homologous recombination (HR) pathway mediated by RAD51. PMID: 22116401
    12. The 657T>C mutation of SYCP3 may not be associated with recurrent miscarriage caused by aneuploidy. PMID: 21357605
    13. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages; heterozygous change, detected in a conserved functional domain of the SYCP3 gene, was absent in >200 controls PMID: 21126912
    14. X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity PMID: 20395201
    15. We suggest that SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein via dominant negative interference. PMID: 14643120
    16. In contrast to previously reported high frequency of SYCP3 mutations in patients with azoospermia, only polymorphisms are found in the present study PMID: 16213863
    17. SYCP3 is expressed in human testis and is restricted to germ cells. Lack of SYCP3 expression in human testis may have a negative effect on spermatogenesis and male fertility. PMID: 16824523
    18. No functional SYCP3 exonic SNP was found in infertile Spanish patients with meiosis arrest, suggesting that SYCP3 mutations very likely are not relevant in Spain in genetic susceptibility to meiosis arrest. PMID: 17434513
    19. These observations suggest that SCP3 is expressed in adult human and monkey ovaries. PMID: 18256545
    20. mutations in SYPR3 are likely to generate an aberrant synaptonemal complex in a dominant-negative manner and contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage. PMID: 19110213

    顯示更多

    收起更多

  • 相關疾病:
    Spermatogenic failure 4 (SPGF4); Pregnancy loss, recurrent, 4 (RPRGL4)
  • 亞細胞定位:
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族:
    XLR/SYCP3 family
  • 組織特異性:
    Testis-specific.
  • 數據庫鏈接:

    HGNC: 18130

    OMIM: 270960

    KEGG: hsa:50511

    STRING: 9606.ENSP00000266743

    UniGene: Hs.506504



主站蜘蛛池模板: 欧美伊人久久大香线蕉综合| 国产三级视频在线播放线观看| 亚洲精品网站在线观看你懂的| 欧美精品一区二区蜜臀亚洲| 亚洲欧美色一区二区三区| 欧美裸体xxxx极品少妇| 亚洲欧美日韩久久精品| 青青青国产在线观看免费| 中文无码av在线亚洲电影| 欧美疯狂做受xxxx高潮| 色欲精品国产一区二区三区av | 国产亚洲精品久久久久久小舞 | 久久精品国产精品国产精品污| 夜鲁鲁鲁夜夜综合视频欧美| 免费无遮挡无码视频网站| 午夜私人成年影院在线观看| 欧美性猛交xxxx三人| 4444亚洲人成无码网在线观看| 18禁裸男晨勃露j毛免费观看| 亚洲中文字幕无码永久| 国产av毛片亚洲含羞草社| 人妻av无码专区久久| 老妇女性较大毛片| 少妇与黑人一二三区无码| 极品少妇扒开粉嫩小泬视频| 99久久国产综合精品五月天喷水| 欧美丰满熟妇bbbbbb| 国产99久久久国产精品免费看| 无码国模大尺度视频在线观看 | 少妇久久久久久被弄高潮| 亚洲成a人片在线不卡一二三区| 吃奶摸下的激烈视频| 无套内射chinesehd熟女| 亚洲欧美不卡高清在线| 野外做受三级视频| 国产精品日本一区二区在线播放| 日本妇人成熟免费视频| 久久成人网站亚洲综合| 日韩av午夜在线观看 | 小12萝裸体视频国产| 激情国产一区二区三区四区|