在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UBE2S Antibody

UBE2S Antibody

  • 中文名稱：
    UBE2S兔多克隆抗體
  • 貨號：
    CSB-PA142614
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA142614(UBE2S Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA142614(UBE2S Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: CSB-PA142614(UBE2S Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AA409170 antibody; E2 EPF antibody; E2-EPF antibody; E2EPF antibody; EPF5 antibody; MGC101982 antibody; Ube2s antibody; UBE2S_HUMAN antibody; Ubiquitin carrier protein S antibody; Ubiquitin conjugating enzyme E2 24 kD antibody; Ubiquitin conjugating enzyme E2 24 kDa antibody; Ubiquitin conjugating enzyme E2 EPF5 antibody; Ubiquitin conjugating enzyme E2 S antibody; Ubiquitin conjugating enzyme E2S antibody; Ubiquitin protein ligase S antibody; Ubiquitin-conjugating enzyme E2 S antibody; Ubiquitin-conjugating enzyme E2-24 kDa antibody; Ubiquitin-conjugating enzyme E2-EPF5 antibody; Ubiquitin-protein ligase S antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human UBE2S
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
  • 基因功能參考文獻：
    1. Ubiquitin-conjugating enzyme E2S (UBE2S) enhanced the ubiquitination of p53 protein to facilitate its degradation in hepatocellular carcinoma (HCC) cells. PMID: 29928880
    2. High UBE2S expression is associated with drug resistance in glioblastoma. PMID: 27593939
    3. RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1. PMID: 28525740
    4. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system. PMID: 28257844
    5. UBE2S is highly expressed in breast cancer PMID: 26245992
    6. Study identified APC/C substrates, including the kinase Nek2A, that require Ube2S for degradation. The reconstitution of Nek2A-ubiquitylation revealed that Ube2S does not simply extend a conjugate but instead branches multiple K11-linked chains off the assemblies produced by Ube2C. PMID: 24813613
    7. E2-EPF is overexpressed in cervical cancer and associates with tumor growth PMID: 22895574
    8. These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in papillary renal cell carcinoma. PMID: 21281817
    9. Linkage-specific ubiquitin chain formation by Ube2S is the result of substrate-assisted catalysis. PMID: 21376237
    10. K11 specificity is determined by an E2 enzyme, UBE2S/E2-EPF, that elongates ubiquitin chains after the substrates are pre-ubiquitinated by UbcH10 or UbcH5. PMID: 20080579
    11. E2-EPF UCP expression induced by growth factors or serum increased HIF-1alpha protein level under non-hypoxic conditions, suggesting that the Egr-1/SRF-UCP-VHL pathway is in part responsible for the increased HIF-1alpha protein level PMID: 18780286
    12. Results suggest that UCP was significantly associated with poor prognosis of esophageal cancer and may be a new molecular target for therapeutic intervention for esophageal squamous cell carcinoma. PMID: 19083192
    13. UBE2S functions with the APC/C in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC activation, providing a new model for APC/C function in human cells PMID: 19820702
    14. UbcH10 and Ube2S constitute a physiological E2-module for anaphase-promoting complex, the activity of which is required for spindle assembly and cell division. PMID: 19822757

    顯示更多

    收起更多

  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 數據庫鏈接：

    HGNC: 17895

    OMIM: 610309

    KEGG: hsa:27338

    STRING: 9606.ENSP00000264552

    UniGene: Hs.396393



主站蜘蛛池模板： 亚洲人成电影在线天堂色| 无码喷水一区二区浪潮av| 久久人搡人人玩人妻精品| 国产免费牲交视频| 影音先锋无码aⅴ男人资源站| 青青青伊人色综合久久| 777精品久无码人妻蜜桃| 少妇白浆呻吟爽| 色又黄又爽18禁免费视频| 在线播放免费人成毛片乱码 | 自拍偷自拍亚洲精品情侣| 亚洲va国产va天堂va久久| 蜜臀av色欲a片无码精品一区| 亚洲中文字幕无码永久| 精品国内综合一区二区| 国产午夜鲁丝片av无码| 国产真实乱人偷精品人妻| 亚洲欧洲日产国码久在线| 成人亚洲一区无码久久| 99久久国产综合精品五月天| 国产疯狂伦交大片| 人妻熟女一区二区aⅴ向井蓝| 欧美尺码专线欧洲b1b1| 国产亚洲tv在线观看| 国产又色又刺激高潮视频| 欧美成a人片在线观看久| 国产va在线观看免费| 亚洲 另类 日韩 制服 无码| 色视频综合无码一区二区三区| 蜜桃av噜噜一区二区三区| 国产精品无码不卡一区二区三区| 国产午夜福利片| 婷婷丁香五月六月综合激情啪| 国产v亚洲v天堂a无码99| 亚洲中文字幕无码日韩精品 | 久久er99国产精品免费| 欧美 亚洲 日韩 中文2019| 日本人妻巨大乳挤奶水| 精品人妻无码专区中文字幕| 精品无码欧美黑人又粗又| 精品综合久久久久久97 |