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  4. Recombinant Human Heat shock factor protein 2 (HSF2 HSTF2)

Recombinant Human Heat shock factor protein 2 (HSF2 HSTF2)

  • 中文名稱：
  • 貨號：
    CSB-YP010792HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP010792HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP010792HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP010792HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP010792HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HSF2
  • Uniprot No.：
  • 別名：
    Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2; HSF2 HSTF2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
  • 基因功能參考文獻：
    1. Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells. PMID: 29799832
    2. HSF2 is a direct target of miR202 with a binding site on 3'-UTR of HSF2 mRNA in esophageal squamous cell carcinoma cells. PMID: 28277193
    3. This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies. PMID: 26119944
    4. Presented are the crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA. PMID: 26727490
    5. the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop. PMID: 26260034
    6. HSF2 can induce histone activation.Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
    7. HSF2 appears to be a potential novel molecular marker for ulcerative colitis PMID: 24533153
    8. the condensed chromatin of HSF2-deficient cells is accessible for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression. PMID: 25202032
    9. These results support a role for HSF2 in the pathogenesis of IA and further implicate this transcription factor as a potential therapeutic target. PMID: 23064888
    10. our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. PMID: 21792930
    11. Data show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2. PMID: 19768582
    12. characterization of the hsf2 gene and its 5'-flanking region PMID: 11795475
    13. HSF2 influences to the formation of nuclear stress granules PMID: 12865437
    14. HSF1 has a role in transcriptional regulation of the human RANK ligand gene PMID: 14699143
    15. results show hsp70i bookmarking is mediated by HSF2 which binds this promoter in mitotic cells, recruits protein phosphatase 2A & interacts with the CAP-G subunit of condensin to promote dephosphorylation & inactivation of condensin complexes PMID: 15662014
    16. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198
    17. During mitosis, HSF2 is bound to the HSE promoter elements of other heat shock genes, including hsp90 and hsp27, and the proto-oncogene c-fos. The presence of HSF2 is important for expression of these genes. PMID: 17915561
    18. MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
    19. These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. PMID: 18570919
    20. NMR study of the SUMOylated DNA binding domain of HSF2 indicates that the SUMO moiety is flexible with respect to the DNA binding domain and has neither a noncovalent interface with nor a structural effect on the domain PMID: 19017645
    21. HSF1-HSF2 heterotrimerization regulates stress-induced transcription PMID: 19129477

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
  • 蛋白家族：
    HSF family
  • 數據庫鏈接：

    HGNC: 5225

    OMIM: 140581

    KEGG: hsa:3298

    STRING: 9606.ENSP00000357440

    UniGene: Hs.158195



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