在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DCK Antibody

  • 中文名稱:
    DCK兔多克隆抗體
  • 貨號:
    CSB-PA006547GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DCK
  • 別名:
    dCK antibody; DCK protein antibody; DCK_HUMAN antibody; Deoxycytidine kinase antibody; Deoxynucleoside kinase antibody; EC 2.7.1 antibody; EC 2.7.1.74 antibody; MGC117410 antibody; MGC138632 antibody; OTTHUMP00000219118 antibody; OTTHUMP00000219119 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DCK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
  • 基因功能參考文獻:
    1. study suggests that DCK knockdown facilitates apoptosis while inhibiting proliferation and tumorigenicity in vivo of cervical cancer HeLa cells. PMID: 28820179
    2. Phosphorylated and activated DCK can inhibit radiation-induced cell death including apoptosis and mitotic catastrophe, and promote radiation-induced autophagy through PI3K/Akt/mTOR pathway. PMID: 27879648
    3. Low deoxycytidine kinase expression is associated with periampullary adenocarcinoma. PMID: 26362587
    4. expression and A9846G AA genotype significantly associated with reduced mortality in pancreatic ductal adenocarcinoma PMID: 26962792
    5. recently described a human deoxycytidine kinase mutant (G12) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12. PMID: 26485161
    6. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA) was significantly lower in ex vivo Ara-C sensitive samples. PMID: 26083014
    7. n the multivariate Cox regression analysis, we found that age at diagnosis, wild-type genotype of the CDA A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death PMID: 26090398
    8. results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of gemcitabine resistance in the RMKN28 tumor cell line PMID: 26196746
    9. DCK rs12648166 and DCK rs4694362 SNPs were associated with hematologic toxicity (OR = 2.63, CI 95% = 1.37-5.04, P = 0.0036 and OR = 2.53, CI 95% = 1.34-4.80, P = 0.0044, respectively). PMID: 25557962
    10. These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance. PMID: 25533931
    11. induction after hypoxia plays a role in the progression of pulmonary fibrosis by contributing to alveolar epithelial cell proliferation PMID: 25358054
    12. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer. PMID: 24618665
    13. DCK could regulate the migration and invasion of fibroblast-like synoviocytes through AKT pathway in rheumatoid arthritis patients. PMID: 24294360
    14. PP2A constitutively dephosphorylates dCK in cells and negatively regulates its activity. PMID: 24462681
    15. Report genetic variation in deoxycytidine kinase and subsequent gemcitabine metabolism. PMID: 23230131
    16. It is evident that the DCK and CDA polymorphisms might be the important markers for the AML patients' therapy outcomes in a Chinese population. PMID: 22884143
    17. Hematologic toxicity such as neutropenia, thrombocytopenia, and anemia were not associated with three tagged single-nucleotide polymorphisms of deoxycytidine kinase or haplotypes. Genetic variations did not affect survival of the patients. PMID: 23035362
    18. High levels of dCK in pancreatic ductal adenocarcinoma predict longer survival times in patients treated with adjuvant gemcitabine. PMID: 22705007
    19. These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance. PMID: 22490663
    20. Although dFdU increased the net intracellular radioactivity of [5-(3)H]dFdC at 24 h in control cells, this increase was abolished in the absence of dCK activity. PMID: 21832002
    21. Data show that the CDA/DCK ratio was 3 fold higher in non-responders than responders (P<.05), suggesting that this could be a mechanism of primary resistance. PMID: 21858090
    22. dCK expression level in fludarabine-sensitive patients was much higher than in Flud-resistant patients. PMID: 20137114
    23. High deoxycytidine kinase is associated with response to pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer. PMID: 21336182
    24. Data show that dCK must make the transition between the open and closed states during the catalytic cycle. PMID: 21351740
    25. Overexpressed dCK and knocked down p8 is associated with enhancement of gemcitabine sensitivity in pancreatic cancer. PMID: 21225236
    26. Data indicate that variant C28624T showed a lower risk of lymphopenia (P=0.04), but a higher risk of neutropenia. PMID: 21030078
    27. We show that ABCG2 influence on clofarabine cytotoxicity was markedly influenced by dCK activity PMID: 21245102
    28. Data show that dCK-360G allele was found to increase the risk of mucositis after exposure to low-dose cytarabine in childhood ALL therapy. PMID: 20890066
    29. Site-directed mutagenesis demonstrated that only Ser-74 phosphorylation was involved in dCK activation by casein kinase 1 delta, strengthening the key role of this residue in the control of dCK activity. PMID: 20637175
    30. Data show that phosphorylation of the three other sites, located in the N-terminal extremity of the protein, does not significantly modify dCK activity, but phosphorylation of Thr-3 could promote dCK stability. PMID: 20544527
    31. Data show that methylation was detected in one of the SP1 binding sites of the dCK promoter, in most tested cancer cell lines and in patient samples from brain tumors and leukemia. Methylation might therefore regulate transcription of dCK. PMID: 20544528
    32. it is residue Asp133 of dCK that is most responsible for discriminating against the thymine base PMID: 20614893
    33. Sensitivity of two pancreatic cancer cell lines transduced with deoxycytidine kinase to gemcitabine elevated dramatically in comparison with control cells. PMID: 20043109
    34. alternatively spliced dCK forms found in acute myeloid leukemia cells play an important role in cytarabine resistance PMID: 11830489
    35. Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells. PMID: 11952160
    36. Data show that inorganic tripolyphosphate (PPP(i)) is a good donor for human ceoxycytidine kinase and deoxyguanosine kinase. PMID: 12535661
    37. human deoxycytidine kinase promoter activity is regulated by USF and Sp1 PMID: 14514691
    38. dCK can act as a phosphorylase, similar to the nucleoside phosphorylase family of enzymes PMID: 15561147
    39. analysis of antitumor drug binding to deoxycytidine kinase PMID: 15571255
    40. dCK expression varies between individual samples and between different types of malignancies and may play a role in resistance to ara-C in particular tumor types PMID: 15571257
    41. deoxycytidine kinase activity is stimulated by 2-chlorodeoxyadenosine and aphidicolin in the cellular context PMID: 15571258
    42. deoxycytidine kinase activity is regulated by reversible phosphorylation PMID: 15571259
    43. an increased expression of mRNA, specific for thymidine kinase 1, dCK and thymidine phosphorylase, may be involved in carcinogenic processes in the human thyroid PMID: 15978330
    44. dCK activity can be controlled by phosphorylation in intact cells, and Ser-74 is required for activity PMID: 16361699
    45. Crystal structures of a deoxycytidine kinase variant lacking a flexible insert (residues 65-79) reveal major changes in the donor base binding loop (residues 240-247) between UDP-bound and ADP-bound forms, involving significant main-chain rearrangement. PMID: 16401075
    46. an increase in activity of dCK, TK1 and 2 might be involved in an adaptive response of cultured human squamous lung carcinoma cells to radiation by facilitation of DNA repair PMID: 16969512
    47. deoxycytidine kinase has a role in lymphoma cell sensitivity to cladribine PMID: 17065053
    48. analysis of phosphorylation sites on human deoxycytidine kinase PMID: 17065079
    49. analysis of deoxycytidine kinase reversible phosphorylation in normal human lymphocytes PMID: 17065080
    50. deoxycytidine kinase activity is enhanced after pulsed low dose rate and single dose gamma irradiation PMID: 17065085

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    DCK/DGK family
  • 數據庫鏈接:

    HGNC: 2704

    OMIM: 125450

    KEGG: hsa:1633

    STRING: 9606.ENSP00000286648

    UniGene: Hs.709



主站蜘蛛池模板: 亚洲日韩成人性av网站| 99re久久资源最新地址| 成人电线在线播放无码| 午夜成人亚洲理论片在线观看| 衣服被扒开强摸双乳18禁网站 | 亚洲最大成人一区久久久| 国产精品国产三级国av| 亚洲中文字幕日产无码2020 | 久久不见久久见免费视频7| 日韩精品一区二区在线观看| 国产精品免费无遮挡无码永久视频| 一区二区三区波多野结衣在线观看| 国产精品 亚洲一区二区三区| 亚洲欧美综合精品成人网站 | 亚洲第一狼人伊人av| 图片区 小说区 区 亚洲五月| 美女无遮挡免费视频网站| av片在线观看免费| 天天躁日日躁狠狠躁2018| 18禁无遮挡羞羞啪啪免费网站| 国产农村妇女高潮大叫| 热99re久久精品| 精品久久亚洲中文无码| 医院人妻闷声隔着帘子被中出| 欧美亚洲色aⅴ大片| 国产精品无码a∨麻豆| 亚洲精品www久久久| 超清中文乱码字幕在线观看| 亚洲熟女精品中文字幕| 日日摸日日碰夜夜爽亚洲综合| 亚洲精品久久久久一区二区| 婷婷成人综合激情在线视频播放| 久久久久人妻一区精品色欧美| 免费一区二区三区成人免费视频| 日本无码人妻精品一区二区蜜桃 | 国产v在线最新观看视频| 国产涩涩视频在线观看| 久久久不卡国产精品一区二区| 国产voyeur精品偷窥222| 天堂在/线资源中文在线8| 国产又色又爽又刺激在线播放 |