在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NAA10 Antibody

  • 中文名稱:
    NAA10兔多克隆抗體
  • 貨號:
    CSB-PA001984GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NAA10
  • 別名:
    Alpha N acetyltransferase 1A antibody; ARD1 antibody; ARD1 homolog N acetyltransferase (S. cerevisiae) antibody; ARD1 homolog A N acetyltransferase (S. cerevisiae) antibody; ARD1 homolog A N acetyltransferase antibody; ARD1A antibody; DXS707 antibody; MGC71248 antibody; N acetyltransferase ARD1, human homolog of antibody; N alpha acetyltransferase 10 NatA catalytic subunit antibody; N terminal acetyltransferase complex ARD1 subunit homolog A antibody; N(alpha) acetyltransferase 10 NatA catalytic subunit antibody; N-alpha-acetyltransferase 10 antibody; N-terminal acetyltransferase complex ARD1 subunit homolog A antibody; Naa10 antibody; NAA10_HUMAN antibody; NatA catalytic subunit antibody; TE2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ARD1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis.
  • 基因功能參考文獻:
    1. Since the FIH-1 dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia. PMID: 30237125
    2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    3. ARD1-mediated Hsp70 acetylation is a regulatory mechanism that temporally balances protein refolding/degradation in response to stress PMID: 27708256
    4. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
    5. A novel de novo NAA10 c.332 T>G p.(Val111Gly) missense variant was detected in a girl with mild/moderate non-syndromic intellectual disability. NAA10 V111G displayed reduced monomeric NAT activity and stability, but intact NatA-mediated NAT activity. PMID: 29558889
    6. Expression of ARD1 increases levels of androgen receptor acetylation and androgen receptor-HSP90 dissociation in a dose dependent manner. PMID: 27659526
    7. Study reports on a total of 12 affected females with four different de novo missense mutations in NAA10 and one inherited mutation in a familial case due to germline mosaicism, thus further expanding themutational and clinical spectrum associated with NAA10 related N-terminal-acetyltransferase deficiency. PMID: 27094817
    8. our study illustrated that the expression of Naa10p had a potential value for predicting the progression of OSCC and prognosis of OSCC patients. PMID: 26662107
    9. The results observed an inverse correlation between the expression of NAA10 and that of miR-342-5p and miR-608 . PMID: 26646451
    10. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
    11. The clinical spectrum of NAA10. PMID: 26522270
    12. there is no difference in lysine acetylation of substrate proteins with or without Naa10, suggesting that the substrates may be acetylated chemically rather than enzymatically. PMID: 26755727
    13. Combined high expression of Naa10p, SNCG and PRL-3 are associated with lymph node metastasis in breast cancer. PMID: 25854368
    14. De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females PMID: 25099252
    15. human ARD1 variants have different effects on cell proliferation, which may result from distinct subcellular localizations and autoacetylation activities. PMID: 25421966
    16. Naa10 structure and function. [Review] PMID: 25987439
    17. Autoacetylation of ARD1 variants differentially regulates angiogenesis and cell proliferation in an isoform-specific manner. PMID: 25338643
    18. ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. PMID: 25341044
    19. Naa10p inhibits the metastasis of breast cancer cells by targeting STAT5a. PMID: 24925029
    20. results show that hARD1 nuclear translocation mediated by NLS is required for cell cycle progression, thereby contributing to proper cell proliferation. PMID: 25133627
    21. Study describes a Saccharomyces cerevisiae model developed by introducing the human wild-type (wt) or mutant NatA complex into yeast lacking NatA (NatA-Delta). The wt human NatA complex phenotypically complemented the NatA-Delta strain, whereas only a partial rescue was observed for the Ogden mutant NatA complex suggesting that hNaa10 S37P is only partially functional in vivo. PMID: 24408909
    22. The study concludes that the NAA10 mutation is the cause of Lenz microphthalmia syndrome in a family, likely through the dysregulation of the retinoic acid signalling pathway. PMID: 24431331
    23. Protein N-terminal acetyltransferases (NATs), including Naa10, act as N-terminal propionyltransferases. PMID: 23043182
    24. Development of the first specific NAT-inhibitors, including inhibitors targeting Naa10. PMID: 23557624
    25. Structural characterization of native hARD1 using size exclusion chromatography, circular dichroism, & fluorescence spectroscopy shows the protein consists of compact globular region comprising 2 thirds of the protein & a flexible unstructured C terminus. PMID: 16823041
    26. ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development PMID: 20145209
    27. These results indicate that ARD1A is a novel tumor-associated antigen and a potential prognostic factor for colon cancer. PMID: 20639454
    28. The expression level of NAA10 is inversely correlated with that of MMP-9 in breast cancer samples. PMID: 23550278
    29. Naa10p suppresses 28S proteasome activity through interaction with PA28beta. PMID: 23624078
    30. These data indicate that the interaction between ARD1 and RIP1 plays an important role in the DNA damage-induced NF-kappaB activation, and that the acetyltransferase activity of ARD1 and its localization in to the nucleus are involved in such stress response. PMID: 22580278
    31. study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription PMID: 22496479
    32. Arrest-defective protein 1 homolog A (ARD1) in combination with SNCG/Hiwi/PRL-3 may lead to a poor outcome in patients with or without lymph node metastatic colon cancer. PMID: 22261620
    33. ARD1 functions as a unique AR regulator in prostate cancer cells. PMID: 22315407
    34. A reduction in acetylation by hNaa10p causes lethal X-linked disorder of infancy. PMID: 21700266
    35. N(alpha)-acetyltransferase 10 may function as a post-translational actin N(alpha)-acetyltransferase. PMID: 21383206
    36. suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells PMID: 21295525
    37. interaction between hNaa10p and DNMT1 was required for E-cadherin silencing through promoter CpG methylation, and E-cadherin repression contributed to the oncogenic effects of hNaa10p. PMID: 20592467
    38. Results show that hARD1 autoacetylation is critical for its activation and its ability to stimulate cancer cell proliferation and tumorigenesis. PMID: 20501853
    39. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
    40. hARD1 is a bona fide regulator of MLCK, and hARD1 plays a crucial role in the balance between tumor cell migration and stasis PMID: 19826488
    41. ARD1-mediated acetylation regulates and destabilizes HIF-1 alpha by directly binding to it. PMID: 12464182
    42. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
    43. Amino-terminal acetyltransferase ARD1 (hARD1) interacts with a novel motif, 658-HGVVEVD-664, in the cytoplasmic domain of beta-amyloid precursor protein. PMID: 15749829
    44. ARD1 is involved in cell proliferation and in regulating a series of cellular metabolic pathways that are regulated during hypoxia response. PMID: 15755738
    45. Data demonstrate that ARD1 has limited, if any, impact on the HIF-1alpha signaling pathway. PMID: 15994306
    46. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
    47. ARD1 specifically binds HIF-1 alpha, suggesting a putative, still unclear, connection between these proteins. PMID: 16288748
    48. A human ARD1 variant ortholog (235) has weak effects on hypoxia inducible factor (HIF)-1 alpha and VEGF mRNA stability compared to mouse ARD1 ortholog 225. PMID: 16376303
    49. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
    50. These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells. PMID: 17161380

    顯示更多

    收起更多

  • 相關疾病:
    N-terminal acetyltransferase deficiency (NATD); Microphthalmia, syndromic, 1 (MCOPS1)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Acetyltransferase family, ARD1 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 18704

    OMIM: 300013

    KEGG: hsa:8260

    STRING: 9606.ENSP00000417763

    UniGene: Hs.433291



主站蜘蛛池模板: 四虎国产精品永久地址入口| 777yyy亚洲精品久久久| 色香阁综合无码国产在线| 国产百合互慰吃奶互揉视频| 国产男女免费完整视频在线| 四虎精品免费永久免费视频| 99久久国产综合精品成人影院| 国产无套中出学生姝| 国产人妻丰满熟妇嗷嗷叫| 婷婷综合久久中文字幕蜜桃三电影| 欧美阿v天堂视频在99线| 亚洲成av大片大片在线播放| 成人网站免费高清视频在线观看| 无码午夜福利免费区久久| 免费观看黄网站在线播放 | 日日碰狠狠躁久久躁蜜桃| 国产免费一区二区三区免费视频| 国产又黄又爽又色的免费| 亚洲性人人天天夜夜摸18禁止| 人妻插b视频一区二区三区| 青青草原综合久久大伊人精品| 久久精品免费一区二区| 久久综合给合久久狠狠狠97色69| 久久无码中文字幕无码| 无码日日模日日碰夜夜爽| 无码日韩精品一区二区免费暖暖 | 99热门精品一区二区三区无码 | 亚洲精品99久久久久中文字幕| 精品 日韩 国产 欧美 视频| 亚洲国产成人精品一区刚刚| 免费乱理伦片在线观看| 在线观看片免费人成视频无码| 熟妇人妻无码中文字幕| 免费无码成人片| 久久精品无码一区二区app| 四虎永久在线精品免费无码| 国产高清自产拍av在线| 搡8o老女人老妇人老熟| 色欲av巨乳无码一区二区| 99热这里只有是精品2| 男女一边摸一边做爽爽|