在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POU2F2 Antibody

  • 中文名稱:
    POU2F2兔多克隆抗體
  • 貨號:
    CSB-PA575296
  • 規格:
    ¥2024
  • 圖片:
    • Immunofluorescence analysis of COS7 cells, using OCT2 antibody.
    • Western blot analysis of extracts from COS7 cells, using OCT2 antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using OCT2 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POU2F2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POU2F2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human OCT2 antibody.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.; Activates the U2 small nuclear RNA (snRNA) promoter.
  • 基因功能參考文獻:
    1. Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. PMID: 28750683
    2. POU2F2 regulated ROBO1 transcription, thus functionally contributing to Gastric cancer metastasis. PMID: 26019213
    3. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function PMID: 27009953
    4. B-cell specific transcription factor, Oct-2, inhibits the function of the viral immediate-early protein, BZLF1, and prevents lytic viral reactivation. Oct-2 potentiates establishment of EBV latency in B cells. PMID: 22346751
    5. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    6. Half of the cases displayed Oct-2 expression (15/30 cases) of systemic anaplastic large-cell lymphoma measured by tissue microarray immunohistochemistry. PMID: 22158496
    7. OCT-2 may act as a cell survival factor in acute myeloid leukemia by mediating expression of downstream targets, such as BCL-2. PMID: 20141429
    8. Gefitinib may exert an inhibitory effect on the intracellular accumulation of drugs transported by hOCT1 and hOCT2. PMID: 20363215
    9. The function of human Oct-2 in immunoglobulin(Ig)-secreting cells requires plasmacytoma-specific coativator OCA-B working synergistically to sustain the gene expression profile of the Ig-secreting cell. PMID: 14662861
    10. DNase I-hypersensitive site 4 (hs4) enhancer activity in mature Burkitt's lymphoma B cells is regulated by synergistic involvement of both Oct-2 and NF-kappa B family members; Oct-2 is required for hs4 enhancer activity. PMID: 14707079
    11. Alteration of the OCT2 locus does not correlate with its suppressed expression in Hodgkin lymphoma. PMID: 15796964
    12. Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2. PMID: 16186795
    13. Oct-2, was studied in detail and found to be a bifunctional regulator: It can either repress or induce neuronal differentiation, depending on the particular isoform PMID: 19270158
    14. Data suggest that OCT2 and/or OCT3 might be involved in the initial component of histamine uptake, whereas the later component of histamine uptake is likely to be mediated by another, as yet undefined uptake system(s). PMID: 19271143
    15. Renal OCT2 expression is no important in the renal excretion of metformin PMID: 19536068

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    POU transcription factor family, Class-2 subfamily
  • 組織特異性:
    Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
  • 數據庫鏈接:

    HGNC: 9213

    OMIM: 164176

    KEGG: hsa:5452

    STRING: 9606.ENSP00000431603

    UniGene: Hs.147381



主站蜘蛛池模板: 亚洲永久网址在线观看| 亚洲成熟丰满熟妇高潮xxxxx| 国产精品三级在线观看无码| 人妻在客厅被c的呻吟| 精品系列无码一区二区三区| 越南女子杂交内射bbwxz| 丝袜熟女国偷自产中文字幕亚洲| 国产高清在线精品一区免费| 精品国产一区二区三区av性色| 亚洲国色天香卡2卡3卡4| 成人美女黄网站色大色费全看| 久久精品国产2020| 少妇性荡欲午夜性开放视频剧场 | 成人午夜高潮免费视频| 又大又粗又爽的少妇免费视频| 无码东京热一区二区三区| 最近最新中文字幕高清免费| 国内精品久久毛片一区二区| 国产高清japanese在线播放e| 国产精品美女久久久久久福利| 国产成人无码a区在线观看视频 | 亚洲理论在线a中文字幕| 国产放荡对白视频在线观看| 性欧美丰满熟妇xxxx性仙踪林| 免费的很黄很污的视频| 国产精品黄页免费高清在线观看| 欧美日产欧美日产国产精品| 日韩少妇人妻vs中文字幕| 久久精品国产99国产精品亚洲| 亚洲综合色在线视频www| 久久精品国产只有精品96| 精品无码人妻一区二区三区| 亚洲男女羞羞无遮挡久久丫| 97超碰国产精品无码分类| 又色又爽又黄的视频日本| 久久精品中文字幕| 亚洲精品一品区二品区三区| 少妇愉情理伦片丰满丰满| 亚洲精品一区二区久久| 天天狠天天透天干天干| 久久人人做人人爽人人av |