在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Saccharomyces cerevisiae ADP,ATP carrier protein 2 (PET9)

  • 中文名稱:
    釀酒酵母PET9重組蛋白
  • 貨號(hào):
    CSB-CF323574SVG
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    PET9
  • Uniprot No.:
  • 別名:
    PET9; AAC2; YBL030C; YBL0421; ADP,ATP carrier protein 2; ADP/ATP translocase 2; Adenine nucleotide translocator 2; ANT 2; Petite colonies protein 9
  • 種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-318
  • 氨基酸序列
    MSSNAQVKTPLPPAPAPKKESNFLIDFLMGGVSAAVAKTAASPIERVKLLIQNQDEMLKQ GTLDRKYAGILDCFKRTATQEGVISFWRGNTANVIRYFPTQALNFAFKDKIKAMFGFKKE EGYAKWFAGNLASGGAAGALSLLFVYSLDYARTRLAADSKSSKKGGARQFNGLIDVYKKT LKSDGVAGLYRGFLPSVVGIVVYRGLYFGMYDSLKPLLLTGSLEGSFLASFLLGWVVTTG ASTCSYPLDTVRRRMMMTSGQAVKYDGAFDCLRKIVAAEGVGSLFKGCGANILRGVAGAG VISMYDQLQMILFGKKFK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.
  • 基因功能參考文獻(xiàn):
    1. Yeast aac2 R96H and aac2 R252G mutations are equivalent to R80H and R235G human ANT1 pathological mutations. mtDNA instability induced by aac2R96H and aac2R252G is rescued by N-acetylcysteine. PMID: 28947214
    2. Mutations in yeast Aac2, equivalent to those in human Ant1 in progressive external ophthalmoplegia, cause protein misfolding. Misfolded Aac2 affects assembly & stability of multiple protein complexes in membrane, which ultimately inhibits cell growth PMID: 25833713
    3. The protective role of cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p). PMID: 23220089
    4. Yeast ADP/ATP carrier isoform 2: conformational dynamics and role of the RRRMMM signature sequence methionines PMID: 21868387
    5. Aac2p and Sal1p may define two parallel pathways that transport a nucleotide substrate in an operational mode distinct from ADP/ATP exchange. PMID: 15238515
    6. The dynamic structural change that occurs in the twisting of the second transmembrane alpha-helix of yeast mitochondrial ADP/ATP carrier (AAC) between matrix-state and cytosol-state gives new insights into the process of AAC substrate translocation. PMID: 15568812
    7. the structural and functional features of the cytosolic-facing first loop (LC1) including its surrounding region PMID: 15628859
    8. The functional form of Ancp is a dimer. PMID: 16274221
    9. Results indicate that the matrix loop m2 of the mitochondrial ADP/ATP carrier intrudes to some extent into the inner mitochondrial membrane and may be involved in the translocation of ADP/ATP. PMID: 16331992
    10. the C-terminal region of the second cytosolic loop in AAC2 changes its environment when the carrier cycles between the matrix and cytosolic state. PMID: 16962388
    11. the residual transport activity in the presence of MTSES depended linearly on the amount of cysteine-less carrier. Thus, the entire transport cycle for ADP/ATP exchange is carried out by the monomer PMID: 17566106
    12. yeast ADP/ATP carriers are monomeric in detergents in agreement with their hydrodynamic properties PMID: 17572439
    13. the Anc2p C-terminal region is involved in nucleotide recognition, binding, and transport PMID: 18299327
    14. Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport. PMID: 18431598
    15. Aac2 exists in physical association with the cytochrome bc1-COX supercomplex and the TIM23 machinery PMID: 18614795
    16. Pathogenic mutations likely enhance the intrinsic proton-conducting activity of adenine nucleotide translocase Aac2, which excessively uncouples the mitochondrial inner membrane thereby affecting energy transduction and mitochondrial biogenesis. PMID: 18809618
    17. Tyr203 and Phe208, aromatic residues of Anc2 transmembrane domain 4 protein carrier, may play a role in nucleotide attraction and its progress through the carrier leading to a productive adenosine diphosphate/adenosine triphosphate exchange. PMID: 19086155

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 數(shù)據(jù)庫鏈接:

    KEGG: sce:YBL030C

    STRING: 4932.YBL030C



主站蜘蛛池模板: 四虎国产精品永久在线无码| 欧美黑人又粗又大久久久| 国产激情高中生呻吟视频| 国产成年无码v片在线| 国产熟女一区二区三区四区五区| 久久精品国产精品| 午夜dj高清免费观看视频| 欧美 在线 成 人怡红院| 欧美精品亚洲精品日韩专区一乛方 | 女人爽到高潮潮喷18禁网站| 岛国4k人妻一区二区三区| 国产成人精品精品日本亚洲| 中日韩精品视频在线观看| 日日噜噜夜夜爽爽| 狠狠人妻久久久久久综合| 蜜桃视频韩日免费播放| 久久国产精品老女人| 九九精品99久久久香蕉| 国产亚洲精品aaaa片app| 色综合av男人的天堂伊人| 国产精品高潮呻吟av久久| 亚洲卡一卡二新区| 草草地址线路①屁屁影院成人| 人妻内射一区二区在线视频| 18禁亚洲深夜福利人口| 国产高清精品软件丝瓜软件| 色久悠悠婷婷综合在线亚洲| 国产卡一卡二卡三无线乱码新区| 日韩伦人妻无码| 亚洲精品成人久久电影网| 午夜亚洲精品久久一区二区| 女人下边被添全过视频的网址| 人与禽性视频77777| 免费看撕开奶罩揉吮奶头视频| 国产精品无码专区第一页| 麻豆国产人妻欲求不满谁演的| 中文字幕无码专区一va亚洲v专区在线| 国语自产偷拍精品视频蜜芽 | 国产成人精品日本亚洲第一区| 精品精品国产男人的天堂| 婷婷丁香五月天综合东京热|