在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa)

  • 中文名稱:
    大鼠Sirpa重組蛋白
  • 貨號:
    CSB-CF021334RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Sirpa; Bit; Mfr; Ptpns1; Shps1; Sirp; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage membrane protein MFP150; Signal-regulatory protein alpha-1; Sirp-alpha-1; CD antigen CD172a
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    32-509
  • 氨基酸序列
    KELKVTQADKSVSVAAGDSATLNCTVSSLTPVGPIKWFKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNNMDFSICISNVTPEDAGTYYCVKFQKGIVEPDTEIKSGGGTTLYVLAKPSSPEVSGPDSRGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLETTISSKSNVSYNISSTVSVKLSPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQPLTPASQVNLTCQVQKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHREDVVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNRAQPTPKPEPSFSEYASVQVQRK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages.
  • 基因功能參考文獻:
    1. In the glomeruli of CNS patients carrying mutations in NPHS1, where SD formation is disrupted, the expression of SIRPalpha as well as Neph1 and nephrin was significantly decreased, indicating that SIRPalpha is closely associated with the nephrin complex PMID: 22747997
    2. Data suggest that hyperglycemia induces increase in association of SHPS-1 with IAP (integrin-associated protein); this appears to be a generalized response of endothelial cells that contributes to endothelial cell dysfunction. PMID: 22193512
    3. Data demonstrate that BIT/SHPS-1 promotes the antiapoptotic effect of BDNF on the low potassium-induced cell death of cerebellar granule neuronss. PMID: 21553247
    4. Data show that myelin down-regulates its own phagocytosis through CD47-SIRPalpha interactions. PMID: 21401967
    5. CD47-SIRP-alpha interaction may be functionally important in cell-cell communication in the diseased glomerulus. PMID: 20554646
    6. BIT is involved in the entrainment of circadian rhythms through the function of NMDARs and non-NMDARs. PMID: 12763253
    7. Gp93 was identified as the Ig superfamily member SIRPalpha (also known as SHPS-1, BIT or P84); in rat brain, gp93/SIRPalpha heterogeneity is the result of differential glycosylation (plus phosphorylation), rather than sequence heterogeneity PMID: 12807424
    8. Tyrosine phosphorylation level of BIT in the retina is higher in the light period than in the dark period. PMID: 14741368
    9. may play a role in the termination of hepatic proliferation during liver regeneration induced by physiological stress or pathological states, such as PH, drugs, toxins PMID: 15047126
    10. BIT is involved in the mechanism of neuronal responses to cold exposure in the hypothalamus PMID: 15158458
    11. the level of the SHPS-1 mRNA increases in rat skeletal muscle after denervation. Glycosylation of SHPS-1 is N-linked in a muscle-specific manner, and that this is altered upon innervation or denervation. PMID: 15858173
    12. SIRPalpha ligation induces macrophage NO production through the cooperative action of JAK/STAT and PI3-K/Rac1/NOX/H(2)O(2) signaling pathways and may function as an activating receptor PMID: 16055727
    13. SIRP alpha and SHP-1 potentially mediate the inhibitory effect of elastic laminae on monocyte adhesion. PMID: 16159885
    14. These results suggest that SIRPalpha functions in the modulation of axonal growth by extracellular matrix molecules, such as laminin. PMID: 16371655
    15. crystallization and X-ray diffraction data collection of the ligand-binding domain of SHPS-1 PMID: 16511298
    16. inhibition by SHPS-1 of phagocytosis in macrophages is mediated, at least in part, in a manner independent of the transinteraction between CD47 and SHPS-1 PMID: 16920950

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Highly expressed in brain, spleen, lung, liver and kidney. Detected at lower levels in heart. Highly expressed in alveolar and peritoneal macrophages, and at lower levels in dendritic cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 中文字幕乱码一区二区三区免费| 國产一二三内射在线看片| 日本人妻巨大乳挤奶水| 精品久久久久久中文字幕| 亚洲小说图区综合在线| 亚洲欲色欲色xxxxx在线观看| 欧美成人高清视频a在线看| 久久成人国产精品| 对白脏话肉麻粗话av| 色欲αv一区二区三区天美传媒| 国产三级视频在线播放线观看| 韩国三级中文字幕hd| 99国产精品99久久久久久| 在线无码中文字幕一区| 日本午夜免a费看大片中文4| 色天使久久综合给合久久97色| 亚洲中文字幕无码久久| 激情内射日本一区二区三区| 亚洲人成亚洲精品| 免费视频成人片在线观看| 妲己丰满人熟妇大尺度人体艺| 午夜三级a三级三点窝| 亚洲人成人无码网www国产| 亚洲欧美人成网站aaa| 国产精品白浆无码流出视频| 无码夜色一区二区三区| 久久香蕉综合色一综合色88| 波多野结衣av高清一区二区三区| 日韩av无码免费播放| 国产偷抇久久精品a片69| 六十熟妇乱子伦视频| 国产人妻久久精品一区二区三区| 少妇一边呻吟一边说使劲视频| 99久无码中文字幕一本久道| 国精品99久9在线 | 免费| 日本精品高清一区二区| 自愉自愉产区二十四区| 免费网禁国产you女网站下载| 久久久久国色av免费观看性色| 男女性杂交内射女bbwxz| 玩弄少妇的肉体k8经典|