在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Transient receptor potential cation channel subfamily V member 5 (Trpv5)

  • 中文名稱:
    大鼠Trpv5重組蛋白
  • 貨號:
    CSB-CF864327RA
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Trpv5
  • Uniprot No.:
  • 別名:
    Trpv5; Cat2; Ecac; Ecac1; Transient receptor potential cation channel subfamily V member 5; TrpV5; Calcium transporter 2; CaT2; Epithelial calcium channel 1; Osm-9-like TRP channel 3; OTRPC3
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-723
  • 氨基酸序列
    MGVKKPWIQLQKRLNWWVREQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKRLQH DQNCDFRQRGALGETALHVAALYDNLDAAIMLMETAPYLVTESTLCEPFVGQTALHIAIM NQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHG ADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHDGGDHLKSLELVPNNQGLTPFKLA GVEGNTVMFQHLMQKRKHIQWSLGPLTSSIYDLTEIDSWGEDLSFLELVVSSKKKEARQI LEQTPVKELVSLKWKKYGQPYFCLLGMLYIFYMICFTTCCVYRPLKFRDANRTHVRDNTV LEQKPLQEAYVTYQDKVRLVGELVTVIGAVVILLIEIPDIFRVGASRYFGHTVLGGPFHV IIITYASLVLLIMVMRLTSMNGEVVPISMALVLGWCSVMYFSRGFQMLGPFTIMIQKMIF GDLLRFCWLMAMVILGFASAFYIIFQTEDPESLGEFSDYPTAMFSTFELFLTIIDGPANY SVDLPFMYHLTYFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERK MPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQ PSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGQDLGEGDGEEI YHF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
  • 基因功能參考文獻:
    1. We demonstrate that under these conditions the TRPV5 C-terminus is exclusively bound to the CaM C-lobe only, while it confers conformational freedom to the CaM N-lobe. We also show that at elevated calcium levels, additional interactions between the TRPV5 C-terminus and CaM N-lobe occur, resulting in formation of a tight 1:1 complex, effectively making the N-lobe the calcium sensor. PMID: 29584409
    2. Study shows that transient receptor potential vanilloid 5 (TRPV5) neurones were conspicuously seen in the hypothalamic paraventricular, supraoptic, accessory neurosecretory, supraoptic nucleus, retrochiasmatic part, arcuate and medial tuberal nuclei, hippocampus, midbrain, brainstem and cerebellum. Results suggest that the TRPV5 ion channel may serve as an important regulator of neural and neuroendocrine pathways in the PMID: 28235149
    3. The up-regulation of TRPV5 stimulated Ca2+ influx, which inhibited autophagy by increasing the production of calmodulin, phosphorylation of calmodulin dependent protein kinases II (p-CAMK II), phosphorylation of Beclin1 (p-Beclin1), and protein of B-cell lymphoma-2 (Bcl-2), and attenuating ratio of LC3-II/ LC3-. PMID: 28535500
    4. Negative calcium balance is associated with suppression of renal cation channel TRPV5. PMID: 24378673
    5. TRPV5 expression is increased in renal tubules following high-sodium diet. PMID: 23199000
    6. Acute hypercalcemia inhibits plasma renin activity via the calcium-sensing receptor because of parathyroid hormone-mediated increases in renal cortical interstitial calcium via TRPV5. PMID: 21825222
    7. Down-regulation of TRPV5 decreases urine calcium reabsorption, directly leading to loss of the urine calcium and resulting in hypercalciuria. PMID: 18846343
    8. the renal transcellular Ca(2+) transport proteins, including TRPV5, could contribute to the pathogenesis of PTH-related disorders PMID: 16164647

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV5 sub-subfamily
  • 組織特異性:
    Detected in kidney (at protein level). Detected in kidney.
  • 數據庫鏈接:


主站蜘蛛池模板: 伊人亚洲综合影院首页| 国产乱子伦农村xxxx| 亚裔大战黑人老外av| 亚洲熟妇色xxxxx亚洲| 免费看撕开奶罩揉吮奶头视频| 成人亚洲a片v一区二区三区动漫| 国产在线无码一区二区三区视频| 影音先锋在线资源无码| av无码人妻无码男人的天堂| 亚洲伦无码中文字幕另类| 热99re久久精品| 亚洲s色大片在线观看| 美女黄频视频大全免费的国内| 久久精品无码一区二区www| 久久欧美一区二区三区性生奴| 狠狠五月深爱婷婷网| 国产在线码观看清码视频| 两性色午夜视频免费无码| 亚洲精品自在在线观看| 最新系列国产专区|亚洲国产| 亚洲超碰无码色中文字幕97| 国产日韩av免费无码一区二区三区 | av免费网站在线观看| 国产又色又爽又黄的| 亚洲欧美日韩视频高清专区| a在线观看免费网站大全| 久久久久99精品成人片直播| 色悠久久久久综合欧美99| 本道久久综合无码中文字幕| 日韩欧美在线综合网另类| 中文字幕乱妇无码av在线| 天天看片天天av免费观看| 国产午夜片无码区在线观看| 精品国产一区二区三区av 性色| 久国产精品人妻aⅴ| 在线精品亚洲一区二区小说| 午夜大片免费男女爽爽影院| 日本丰满熟妇bbxbbxhd| 不卡av中文字幕手机看| 精品无人码麻豆乱码1区2区| 欧美性猛交xxxx乱大交极品|