在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Pannexin-1 (Panx1)

  • 中文名稱:
    大鼠Panx1重組蛋白
  • 貨號(hào):
    CSB-CF017425RA
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Panx1; Px1; Pannexin-1
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-426
  • 氨基酸序列
    MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL YLPALFWRFAAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQ SLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFAVVLLACIYLSYYFSLSSLS DEFLCSIKSGVLRNDSTIPDSFQCKLIAVGIFQLLSLINLLVYALLVPVVIYTLFVPFRQ KTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGI DPMLLLTNLGMIKMDVIDGKVPMSLQTKGEDQGSQRMDFKDLDLSSETAANNGEKNSRQR LLNSSC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
  • 基因功能參考文獻(xiàn):
    1. the upregulation of Pannexin1 expression may be involved in apoptosis and degeneration of neurons in the rat brain following ICH, and may contribute to subsequent cognitive dysfunction. PMID: 29484398
    2. panx1 contributes to distension- or LPS-evoked ATP release into the lumen of the bladder and that luminal release can modulate voiding function. PMID: 25630792
    3. Px1 channels releasing ATP have any role in the constrictor actions of alpha1-adrenoceptor activation PMID: 25637780
    4. These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs PMID: 25170954
    5. It was shown that angiotensin signaling in type II cells activates an inward current carried by Panx1 channels. PMID: 25172944
    6. ETV4 and cAMP response elements play a role in the transcriptional regulation of Panx1 in the epididymis. PMID: 25376229
    7. Panx1 up-regulation contributes to pain hypersensitivity induced by nerve injury. PMID: 25925949
    8. Study found that astrocytes released ATP in response to mechanical strain, with pannexin 1 the predominant efflux pathway PMID: 24839011
    9. Pannexin-1 hemichannels regulate urothelial overactivity in the bladder via activation of uracil nucleotidetide (UDP)-sensitive P2Y6 receptors. PMID: 24269631
    10. These results suggest that panx1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated FFA; panx1 may play a role in hepatic inflammation by mediating an increase in extracellular ATP concentration in lipotoxic liver injury. PMID: 22972801
    11. Activation of NMDA receptors during anoxia/ischemia recruits Src family kinases to open Panx1 channels, leading to sustained neuronal depolarizations. PMID: 22956847
    12. pannexin 1 is expressed in smooth muscle but not in endothelium of middle cerebral arteries. PMID: 22301733
    13. The results suggest that Panx1c and Panx1d may serve as dominant-negative effectors to modulate the functions of Panx1a through formation of heteromeric channels. PMID: 21907716
    14. ATP, released through Px1 hemichannels, activates purinergic P2X7 receptors, resulting in the closure of Px1 hemichannels during ischemia. PMID: 21185900
    15. Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP. PMID: 21467198
    16. indicate that the oligomerization and trafficking of Panx1 are regulated by the C-terminal domain, whereas internalization of long lived Panx1 channels occurs in a manner that is distinct from classical endocytic pathways PMID: 21659516
    17. In the testis, Panx1 localized to the basal compartment of the seminiferous epithelium, while Panx3 was expressed in Leydig cells. In the ED, both Panxs were expressed in the apical region of ciliated cells. PMID: 21337450
    18. Panx1 channels potentially promote arrhythmogenic activities. PMID: 21041301
    19. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other PMID: 20516070
    20. Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation. PMID: 20332104
    21. New insight into relationship of decreased glucose to increased seizure threshold is established through neuronal adenosine triphosphate (ATP) release via pannexin hemichannels and hippocampal adenosine A1 receptors coupled to potassium ATP channels. PMID: 20237259
    22. although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules PMID: 20086016
    23. the different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions. PMID: 14597722
    24. Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons PMID: 16616526
    25. Has kinetics and dynamics that make it unique to serve distinct functions separate from connexin-based channels. PMID: 18649184
    26. Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. PMID: 19009624
    27. study concludes that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity PMID: 19056988
    28. in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1 PMID: 19416975

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Pannexin family
  • 組織特異性:
    Expressed in the eye, thyroid, prostate, kidney and liver. Abundantly expressed in the CNS, including hippocampus, olfactory bulb, cortex, cerebellum and white matter.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产成人一区二区不卡免费视频| 精品欧美аv高清免费视频| 999国内精品永久免费视频| 在线观看国产精品普通话对白精品| 吃奶摸下高潮60分钟免费视频| 婷婷开心激情综合五月天| 国产成人精品一区二区秒拍| 99精品免视看| 韩国19禁主播深夜福利视频| 国内精品久久久久久久影视| 看曰本女人大战黑人视频| 国产欧美精品一区二区三区四区| 偷窥村妇洗澡毛毛多| 内射夜晚在线观看| 67194成是人免费无码| 国产福利一区二区三区在线视频| 少妇大叫太大太爽受不了在线观看 | 欧美成人一区二免费视频软件| 成人亚洲a片v一区二区三区动漫| 国产欧美综合在线观看第十页 | 色哟哟免费视频播放网站| 麻豆精品国产精华精华液好用吗 | 国产片av国语在线观麻豆| 精品视频国产狼友视频| 国产精品成人a区在线观看| 无遮无挡爽爽免费毛片| 无码人妻aⅴ一区二区三区| 亚洲精品国产第一综合99久久| 老子影院无码午夜伦不卡| a欧美爰片久久毛片a片| 亚洲国产成人超a在线播放| 日韩 欧美 国产 一区三| 亚洲精品乱码久久久久久日本 | 久久婷婷五月综合色国产香蕉| 国产乱妇乱子视频在播放| 99精品国产免费观看视频| 国产精品久久久久久亚洲色| 久久性色av亚洲电影| 99精品全国免费观看视频| 蜜桃传媒av免费观看麻豆| 久久婷婷人人澡人人爽人人喊|