在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat P2Y purinoceptor 12 (P2ry12)

  • 中文名稱:
    大鼠P2ry12重組蛋白
  • 貨號:
    CSB-CF872110RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    P2ry12; P2y12; P2Y purinoceptor 12; P2Y12; P2Y12 platelet ADP receptor
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-343
  • 氨基酸序列
    MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.
  • 基因功能參考文獻:
    1. Gene expression of the purinergic P2Y12 subtype was detected in rat retina during early postnatal days (P0 to P5), while expression levels of P2Y13 were low. PMID: 29574630
    2. Establish a reliable antiplatelet profile of SAR216471, and support its potential use in clinical practice as an alternative to currently available P2Y12 receptor antagonists. PMID: 25064036
    3. Data indicate that endothelium-dependent relaxation as well as contractile vascular responses actions are not mediated by purinergic receptor P2Y G-protein coupled 12 (P2Y12) activation. PMID: 19811450
    4. study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways PMID: 24971933
    5. Notoginsenoside Ft1, a saponin isolated from Panax notoginseng, enhanced platelet aggregation by activating a signalling network mediated through P2Y12 receptors. PMID: 24117220
    6. Platelet ADP and AA receptor inhibition is a prominent early feature of coagulopathy in traumatic brain injury in humans and rats and is linked to the severity of brain injury in patients with isolated head trauma. PMID: 24747445
    7. Expression of P2Y12 receptors is necessary for autotaxin's MORFO domain to exert its effects on differentiating oligodendrocytes. PMID: 22139091
    8. Findings provide the first evidence that the activation of P2Y12R in SGCs of TG following lingual nerve injury is involved in the enhancement of TG neuron activity and nocifensive reflex behavior, resulting in neuropathic pain in the tongue. PMID: 22458630
    9. These findings indicate that ATP induces the integrin-beta1 activation in microglia through P2Y(12) and suggest that the integrin-beta1 activation is involved in the directional process extension by microglia in brain tissue. PMID: 20091784
    10. A cAMP-dependent inhibition of protein kinase B induces differentiation of C6 glioma cells, and inhibition of adenylate cyclase and reactivation of the PI 3-kinase/PKB pathway by the P2Y(12) receptor reverses differentiation into enhanced proliferation PMID: 15056287
    11. secretion of endogenous ADP and subsequent P2Y12-mediated signaling are critical for platelet aggregation, platelet spreading, and as a consequence, for stabilization of thrombus PMID: 16194207
    12. The adult rat CNS the cellular/subcellular distribution of P2Y12 receptor protein in cerebral cortex, white matter and subcortical nuclei (striatum and substantia nigra). PMID: 16831517
    13. Activation of vascular and glomerular purinergic P2 receptors (P2Y12) may contribute to the mesangial cell transformation, renal inflammation, and vascular hypertrophy observed in ANG II-dependent hypertension. PMID: 17989111
    14. Knockdown of P2Y12 receptor expression suppresses the development of pain behaviors. PMID: 18337420
    15. Activation of P2Y(12)Rs in spinal microglia may be critical event in pathogenesis of neuropathic pain. Blocking microglial P2Y(12)R might be viable therapeutic strategy for treating neuropathic pain. PMID: 18463248

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 人人妻人人澡人人爽欧美一区九九| 亚洲中文字幕a∨在线| 日韩不卡1卡2卡三卡网站| 亚洲精品无码国产片| 老鸭窝视频在线观看| 久久这里只精品国产免费9| 国产精品福利2020久久| 亚洲人成网7777777国产| 国产精品久久久久久吹潮 | 熟女俱乐部五十路六十路av| 国产精品高潮呻吟av久久小说| 国产成人无码精品久久涩吧| 亚洲欧美日韩综合俺去了| 污污内射久久一区二区欧美日韩| 国产aⅴ激情无码久久久无码| 国内精品乱码卡一卡2卡麻豆| 羞国产在线拍揄自揄视频| 一本一道人人妻人人妻αv| 人与禽性视频77777| 亚洲乱码av中文一区二区软件| 免费无码肉片在线观看| 国偷自产av一区二区三区| 青草青草久热国产精品| 一本清日本在线视频精品| 国产精品久久久久久av| 午夜片神马影院福利| 亚洲人成无码网站18禁10| 久久一卡二卡三卡四卡| 亚洲色欲色欲www在线丝| 日韩 无码 偷拍 中文字幕 | 久久精品日日躁夜夜躁| 国产一在线精品一区在线观看| 国产97在线 | 中文| 国产人无码a在线西瓜影音| 亚洲熟妇av一区| 西西人体www大胆高清视频| 秋霞午夜久久午夜精品| 欧美大香线蕉线伊人久久| 久久久久波多野结衣高潮| 国产未发育呦交视频| 亚洲欧洲日产无码中文字幕|