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Recombinant Rat P2Y purinoceptor 1 (P2ry1)

  • 中文名稱:
    大鼠P2ry1重組蛋白
  • 貨號:
    CSB-CF017326RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    P2ry1; P2Y purinoceptor 1; P2Y1; ATP receptor; Purinergic receptor
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-373
  • 氨基酸序列
    MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYIL VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG DVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVV VAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLI VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFND RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLN ILSEFKQNGDTSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
  • 基因功能參考文獻:
    1. P2Y1R plays a regulatory role in visceral hypersensitivity in rats with experimental irritable bowel syndrome. PMID: 28974901
    2. These data are supporting the idea of a dynamic modulation of astrocytic processes by purinergic signal, strengthening the role of purines in brain homeostasis. PMID: 27318677
    3. Data indicate the involvement of P2Y1Rs in interleukin-1beta (IL-1beta) mediated pain in both naive and carrageenan injected rats. There is a positive interaction between peripheral P2Y1Rs and interleukin-1 receptors in both IL-1beta and carrageenan-induced thermal hypersensitivity. PMID: 28153540
    4. Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy. PMID: 26743169
    5. Data demonstrate that P2X7 and P2Y1 activation contributes to early damage induced by oxygen and glucose deprivation in the dentate gyrus (DG) with perhaps additional role for P2Y1 receptors in promoting cell proliferation and maturation in the DG. PMID: 25526634
    6. Results suggest that activation of P2Y1 receptors in the medial prefrontal cortex impairs inhibitory control and behavioral flexibility mediated by increased mesocorticolimbic activity and local disinhibition PMID: 25027332
    7. P2Y1 receptors are a potential pharmacological target leading smooth muscle relaxation to treat spasticity in colonic motor disorders. PMID: 24998877
    8. Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain. PMID: 25449358
    9. P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro PMID: 24879869
    10. FAM3A promotes proliferation and migration of vascular smooth muscle cells via P2Y1 receptor-mediated activation of Akt and ERK1/2 pathways. PMID: 24857820
    11. fibronectin upregulated the expression of P2Y1 receptor in spinal cord, and ATP could enhance the astrocytic proliferation and induce more release of arachidonic acid and prostaglandin E2 via P2Y1. PMID: 24687862
    12. P2Y1 receptors in astrocytes inhibit GABA transport through a mechanism dependent of P2Y1-mediated calcium signalling PMID: 24733747
    13. maintenance of an acidic environment in the ischemic hind paw of thrombus-induced ischemic pain rats results in the phosphorylation of TRPV1 receptors via a PKC-dependent pathway and P2Y1 receptor. PMID: 24401144
    14. It was concluded that the glomeruli podocytes and P2Y1 might be involved in the pathogenesis of glomerular injury and could be a target for treatment of kidney diseases. PMID: 24048730
    15. data identify P2Y1 receptors as key determinants of peripheral chemoreceptor regulation of breathing, sympathetic nerve activity, and blood pressure PMID: 23753413
    16. P2Y(1) -receptor-mediated vasodilatation is impaired in superior mesenteric arteries from long-term type 1 diabetic rats. PMID: 22759594
    17. The response of acinar cells to ATP is mediated by P2Y (especially P2Y) as well as by P2X purinoceptors. PMID: 22065011
    18. Data show that the inhibition of P2Y1 purinergic receptor (P2Y1R)-mediated extracellular signal-regulated protein kinase 1/2 (ERK1/2) phosphorylation in the spinal cord and dorsal root ganglia can attenuate nociception transmission. PMID: 22349022
    19. Critical roles are suggested for activating P2Yreceptors and mediating glioma cell mobility and migration, with changes in divalent calcium ions as a mechanistic link between activated receptor and functional response. PMID: 21540076
    20. In immunogold electron microscopy, labeling for P2Y1, P2Y6, and P2Y12 receptors were predominantly localized in the basal part of endothelial cells. PMID: 21879346
    21. P2ry1 and phosphorylated-RelA are localized in astrocytes and are key mediators of brain damage during ischemia and reperfusion injury. PMID: 21487414
    22. these data suggest that the reduction of Ca(2+) influx via voltage-gated Ca channels caused by the activation of P2Y(1) receptors by ATP is the possible mechanism for the inhibition of long-term depression in prefrontal cortex. PMID: 20570683
    23. NHERF2 selectively restricts downstream coupling of mGluR5 and P2Y1Rs in neurons to G(q)-mediated responses. Differential distribution of NHERF2 in neurons may therefore determine coupling of mGluR5 and P2Y1 receptors to calcium channels. PMID: 20720114
    24. in rat colon, a co-transmission process that involves ATP through P2Y1 receptors, and nitric oxide is present; P2Y1 receptors are responsible for the fast component of the inhibitory junction potentials PMID: 19906120
    25. These observations indicate that astrocytic P2Y(1) receptor activation triggered glutamate efflux, which acts on distant neurons to elevate calcium levels or acts on nearby neurons to evoke inward current. PMID: 19396875
    26. ATP and adenosine play a complementary role in ischemic preconditioning through P2Y purinoceptors and adenosine receptors PMID: 11959647
    27. Colocalization of P2Y1 receptors and neuronal NOS (nNOS) is demonstrated on neurons in the dorsomedial hypothalamic nucleus and suggests that P2Y1 receptors are involved in mediating nitric oxide production in the rat. PMID: 12629523
    28. Both P2Y1 and P2Y2 receptors are present in cerebral arterioles; Low amounts of ATP stimulate P2Y1 receptors and high levels activate P2Y2. Nitric oxide is involved in P2Y1 but not P2Y2 activation; potassium channels regulate the vasodilation PMID: 12730558
    29. Agonist activation of P2Y2 receptor by adenosine 5'-O-(3-thiotriphosphate) enhanced release of PGE2 from inner medullary collecting duct in time- and concentration-dependent fashion. PMID: 12799304
    30. immunostaining of pancreas from streptozotocin-diabetic rats revealed P2Y1 receptors present in intra-islet capillaries; P2Y1 and P2Y2 receptors present in pancreatic duct cells; and P2X1, P2X2, P2Y1 and P2Y2 receptors present in small blood vessels. PMID: 12850289
    31. P2Y as well as P2X receptor subtypes contribute to purinergic signalling in sensory ganglia. PMID: 14564529
    32. P2Y receptor-evoked Ca2+ mobilization in rat megakaryocytes is controlled by membrane voltage in a graded and bipolar manner without evidence for a discrete threshold potential. PMID: 14645457
    33. Slow binding sites could be assigned to the same P2Y1 receptor subtype in brain membranes while the 'fast' binding sites belong to other membrane-bound proteins, also interacting with ATP and its analogues. PMID: 14729222
    34. P2Y1 receptor was detected in a subset of taste bud cells of fungiform, foliate, and circumvallate papillae. PMID: 15103469
    35. P2Y1 receptors are in the apical membrane of the rat proximal tubule: receptor activation impairs acidification in this nephron segment. PMID: 15172882
    36. ATP acts on P2Y1 receptors coupled to Gq/11, resulting in the upregulation of oxidoreductase genes, leading to the protection of astrocytes against H2O2. PMID: 15494980
    37. the voltage dependence to Ca2+ release via Galphaq-coupled receptors is not due to control of G-proteins or down-stream signals but, rather, can be explained by a voltage sensitivity at the level of the P2Y1 receptor itself PMID: 15528188
    38. In hippocampal slices, ATP activates P2Y1 receptors in the interneurons, which is linked to activation of unidentified excitatory conductance, through mechanisms distinct from those in the astrocytes. PMID: 15574734
    39. ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus, the inhibition being mediated by P2Y1, P2Y2, and/or P2Y4 PMID: 16000618
    40. Extracellular ATP induces a transient contractile response in human and rat airways, mainly due to P2X receptors and extracellular Ca2+ influx in addition with, in IPB, P2Y receptors stimulation and Ca2+ release from intracellular Ca2+ stores. PMID: 16336659
    41. We conclude that ligand-receptor binding leads to rapid endocytosis in the cytoplasm of rat dorsal root ganglion neurons. PMID: 16624826
    42. Restricted feeding may enhance the sensitivity of the hypothalamus to extracellular ADP/ATP by regulation of the expression of P2Y1 receptors and of their signal transduction pathway via nitric oxide production. PMID: 16643864
    43. analysis of the coupling of purinergic P2Y1R to glutamate exocytosis and its peculiar TNFalpha- and PG-dependent control PMID: 16882655
    44. Taken together, ATP, acting on P2Y(1) receptors, upregulates the PTP expression and its activity, which counteracts the H(2)O(2)-promoted death signaling cascades including ERK1/2 and its upstream signal src tyrosine kinase in astrocytes. PMID: 16944453
    45. This data indicates that P2Y1, P2Y2 and P2Y12 receptor proteins exist within mitochondria of astrocytes and C6 cells, although their role in these sub-cellular structures remains unclear. PMID: 17292801
    46. Data show that the P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex. PMID: 17598884
    47. The present results show a time-, region- and cell type-dependent in vitro and in vivo expression pattern of different P2 receptor subtypes in the dopaminergic system. PMID: 17869006
    48. P2Y(1)-mediated Ca(2+) sustain was at least in part via P2X receptors activated by the P2Y(1)-induced ATP release, and PKC played a pivotal role in desensitization of P2Y(1) receptors in RBA-2 astrocytes PMID: 18072286
    49. The P2Y(1)R-mediated frequency increase to ATP is likely to reflect activation of a mixed cationic conductance in multiple types of preBotC neurone than excitation of one, highly sensitive group. PMID: 18174215
    50. EFS-evoked norepinephrine outflow in the hippocampus is inhibited by P2Y1 receptors. Activation of facilitatory and inhibitory P2 receptors may participate in the modulation of NA release under ischemic-like conditions. PMID: 18384646

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  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in muscle, heart, liver, kidney, lung, brain, spleen, but not in testis.
  • 數據庫鏈接:


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