在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Neuropeptide Y receptor type 5 (Npy5r)

  • 中文名稱:
    大鼠Npy5r重組蛋白
  • 貨號:
    CSB-CF714347RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Npy5r; Npyr5; Neuropeptide Y receptor type 5; NPY5-R; NPY-Y5 receptor; NPYY5-R; Y5 receptor
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-445
  • 氨基酸序列
    MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNL LILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL VELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC GLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAP AGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKK RSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLN PILYGFLNNGIKADLRALIHCLHMS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
  • 基因功能參考文獻:
    1. NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage PMID: 28057538
    2. long-term over-expression of NPY in paraventricular nucleus contributes to the establishment of adipose tissue insulin resistance, at least partly via the Y5 receptor PMID: 25993471
    3. Our results showed the altered expression of NPY, Y1R and Y2R but not Y5R in hippocampus and temporal lobe cortex of tremor rat brain. PMID: 24444822
    4. Y5R does no tparticipate in the anorectic response to phenylpropanolamine. PMID: 23179670
    5. results suggest that while signals mediated through NPY Y1 receptors play a modest role in reinstatement, activation of Y5 receptors has a critical function in food deprivation-induced reinstatement of heroin-seeking behavior. PMID: 21629996
    6. the inhibition of central Y5 neurotransmission resulted in activation of thyroid axis during fasting suggesting that NPY-Y5 receptors contribute to fasting-induced TSH and TH suppression PMID: 21771616
    7. NPY and Y5R expression increased by more than 130-fold and decreased by 28-fold, respectively, in old bone marrow cells as compared to young bone marrow cells. PMID: 21595512
    8. via a specific Y-1R/Y-5R interplay, NPY acts as a neuroimmune co-transmitter in vivo. PMID: 12417430
    9. data suggest that over activity of the neuropeptide Y, neuropeptide Y-1 receptor, and neuropeptide Y-5 receptor gene expression may contribute to the development of obesity in OM rats PMID: 12429884
    10. data confirm the importance of both neuropeptide Y1 and Y5 receptors in the neuropeptide Y-mediated increase in food consumption and demonstrate that both receptors can mediate inhibitory effects of neuropeptide Y on the hypothalamo-pituitary-thyroid axis PMID: 12446577
    11. Comparative mapping of Y1 and Y5 receptor subtypes within cell bodies and nerve fibers in the brain which, together with physiological and electrophysiological studies, provide a better understanding of NPY neural circuitries. PMID: 12900925
    12. decreased expression and number of Y(5) receptors in the hypothalamic paraventricular nucleus cannot explain the attenuated responsiveness of the senescent rats to exogenous neuropeptide Y PMID: 15044185
    13. we investigated the regulation of BDNF and NPY mRNA and Y1-, Y2-, and Y5-like receptor binding in the hippocampus of vehicle-pretreated, partially and fully amygdala-kindled rats and corresponding levetiracetam-pretreated rats (40 mg/kg i.p.). PMID: 15123022
    14. data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation PMID: 15544855
    15. Y5 receptors mediate inhibitory effects of NPY in kindling and display anticonvulsant rather then antiepileptogenic effects upon agonist stimulation PMID: 15582717
    16. Results describe the distribution of neuropeptide Y Y5 receptor-like immunoreactivity in the rat brain. PMID: 16954600
    17. Selective stimulation of Y(5) receptor provokes activation of the HPA axis and its downstream pathway is chiefly composed of both CRF (primary regulator) and AVP (subordinate to the former) with distinct relative contribution. PMID: 17363455
    18. These results suggest that in addition to regulating feeding behaviour, the Y5 receptor subtype may have previously unrecognised roles in the control of nesting behaviour during lactation with subsequent effects on litter growth rates. PMID: 19419662

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Brain; hypothalamus.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲高清最新av网站| 中文字幕一区二区三区日韩精品| 中文字幕人妻熟女人妻洋洋| 欧美肥胖老太vidio在线视频| 国产精品一区二区香蕉| 开心色婷婷色五月激情| 欧美日韩无线码在线观看| 男女无遮挡激情视频| 人妻激情偷乱视频一区二区三区| 人人妻人人澡人人爽欧美一区九九| 香蕉欧美成人精品a∨在线观看 | 天堂中文在线最新版地址| 熟妇人妻系列av无码一区二区| 久久精品国产99久久久古代| 免费毛片a线观看| av免费播放一区二区三区| 中文字幕久久精品无码| 欧美人与物videos另类| 亚洲国产精品综合久久网络| 精品自拍亚洲一区在线| 亚洲kkk4444在线观看| 色久悠悠婷婷综合在线亚洲| 成年美女黄网站色大免费视频| 欧美艳星nikki激情办公室| 色v99在线影院| 欧美日产欧美日产国产精品| 五十路熟女一区二区三区| 久久精品中文字幕无码绿巨人 | 亚洲女教师丝祙在线播放| 极品少妇被弄得高潮不断| 中文字幕 人妻熟女| 高h纯肉无码视频在线观看| 午夜精品电影你懂的| 97精品尹人久久大香线蕉| 免费人成激情视频在线观看冫| 亚洲精品久久区二区三区蜜桃臀| 欧美牲交a欧美牲交vdo18| 亚洲性线免费观看视频成熟| 天天做天天爱夜夜爽毛片毛片| 国产精品9999久久久久仙踪林| 日韩人妻熟女中文字幕aⅴ春菜|