在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Mitofusin-1 (Mfn1)

  • 中文名稱(chēng):
    大鼠Mfn1重組蛋白
  • 貨號(hào):
    CSB-CF840297RA
  • 規(guī)格:
  • 來(lái)源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Mfn1; Fzo1b; Mitofusin-1; Mitochondrial transmembrane GTPase FZO1B; Transmembrane GTPase MFN1
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-741
  • 氨基酸序列
    MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGY RNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDG DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSP GTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD ASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMP EGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNV AAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRL SVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENL KPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTN AQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGII VVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKF TSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAV QLERELENFSKQFLHPSSGES
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.
  • 基因功能參考文獻(xiàn):
    1. Hypoxia leads to upregulation of mitofusin 1 (Mfn1) both in vivo and in vitro. Mfn1 is involved in hypoxia-induced PASMCs proliferation. Mfn1-mediated mitochondrial homeostasis is regulated by miR-125a. MiR-125a plays a role in PASMCs oxidative phosphorylation and glycolysis. PMID: 28593577
    2. results implied that HO-1 upregulation suppressed oxidative stress induced by LPS, and the possible mechanism could be associated with Mfn1 and the PI3K/Akt pathway. PMID: 27830717
    3. Studied role of plant-derived miR5338 in Mfn1 inhibition in rape bee pollen treatment for benign prostatic hyperplasia. PMID: 29382326
    4. In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated. PMID: 24958380
    5. Data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis. PMID: 25801171
    6. Mfn1 and miR-140 are integrated into the program of cardiomyocyte apoptosis. PMID: 24615014
    7. Physical exercise is identified as a preventive measure to promote mitochondrial function and expressions of mitofusin, BDNF and antioxidant in brain, so as to protect brain energy metabolism against chronic mild stress. PMID: 22244747
    8. The Mfn 1 could inhibit the activation of caspase-3 and caspase-9, which are necessary for endonuclease G translocation to the nucleus. PMID: 20594982
    9. Fis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis. PMID: 18832378

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily
  • 組織特異性:
    Ubiquitous. In brain, it is expressed at weaker level than MFN2, while it is expressed at a higher level than MFN2 in heart and testis. Expressed at high level in elongating spermatids of seminiferous tubules.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 日韩成人无码| 少妇做爰免费视频了| 国产又色又爽又黄的| 中文字幕亚洲制服在线看| 中文国产成人精品久久久| 蜜臀av色欲a片无码一区二区| 97久久精品人人澡人人爽| 天天做天天爱天天综合网2021| 亚洲国产成av人天堂无码| 2021国产成人精品久久| 粉嫩av久久一区二区三区| 青春草在线视频免费观看| 亚洲444kkkk在线观看| 真正免费毛片在线播放| 香港三级精品三级在线专区| 偷偷做久久久久网站| 亚洲欧洲日产国产 最新| 亚洲狠狠婷婷综合久久久久图片| 内射老妇bbwx0c0ck| 久久视频这里有精品33| 麻豆视传媒官网免费观看| 伴郎粗大的内捧猛烈进出视频观看| 成人综合网站| 最新国产aⅴ精品无码| 亚洲精品区午夜亚洲精品区| 国产精品51麻豆cm传媒| 又色又爽又黄的gif动态图| 日本少妇浓毛bbwbbwbbw| 国产乱沈阳女人高潮乱叫老| 18禁裸乳无遮挡啪啪无码免费 | 大尺度无遮挡激烈床震网站| 国产白嫩美女在线观看| 欧美 国产日韩 综合在线| 久久久无码精品国产一区| 无码专区久久综合久中文字幕| 中字幕人妻一区二区三区| 国产精品乱子伦xxxx裸| 久久久免费无码成人影片| 久久99成人免费| 久久亚洲精品无码爱剪辑| 天堂中文在线8最新版地址|