在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Free fatty acid receptor 2 (Ffar2)

  • 中文名稱:
    大鼠Ffar2重組蛋白
  • 貨號:
    CSB-CF008605RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Ffar2; Gpr43; Free fatty acid receptor 2; G-protein coupled receptor 43
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-330
  • 氨基酸序列
    MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLL LLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS RRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVR LELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNM SHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLG RGAEETVEGTKTDRGGSQTEGAQSSDFVTE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
  • 基因功能參考文獻:
    1. up-regulation of GPR43 and GPR120 in response to a high fat diet, is tissue specific PMID: 22178946
    2. The results suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor. PMID: 16453106
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Detected in whole wall and separated mucosa in the distal ileum and colon. Expressed by enteroendocrine cells expressing peptide YY (PYY) (at protein level).
  • 數據庫鏈接:


主站蜘蛛池模板: 最新国产精品好看的精品| 亚洲国产精品无码av| 亚洲精品国偷自产在线99人热| 国产无套粉嫩白浆在线观看| 午夜三级a三级三点在线观看| 国产成年无码v片在线| 一本一道波多野结衣av一区 | 丰满的人妻hd高清日本| 亚洲欧美日韩成人一区二区三区| 亚洲人成无码网站18禁10| 亚洲色播永久网址大全| 强行无套内谢大学生初次| 性色av蜜臀av色欲av| 久久久国产精品亚洲一区| 好了av在线第四综合网站| 好爽太紧了舒服视频| 国色天香在线视频www| 久久天天躁狠狠躁夜夜avapp| 欧美极品少妇性运交| 一本天堂v无码亚洲道久久| 最新亚洲中文av在线不卡| 欧美黑人xxxx高潮猛交| 精品亚洲成a人片在线观看少妇 | 精品一区二区国产在线观看| 国产内射一区亚洲| 大屁股熟女一区二区三区| 性生交大片免费看女人按摩| 伊人蕉久中文字幕无码专区 | 亚洲人色婷婷成人网站在线观看| 国产熟妇久久777777| 好紧好爽好湿别拔出来视频男男| 久久久av男人的天堂| 人妻插b视频一区二区三区| 欧美精品无码一区二区三区| 麻豆精品国产精华精华液好用吗| 久久久久久久岛国免费观看 | 成人免费国产精品视频| 欧美精品中文字幕亚洲专区| 日韩成人无码v清免费 | 久久人人爽人人爽爽久久小说| 激情内射亚洲一区二区三区|