在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Follicle-stimulating hormone receptor (Fshr)-VLPs

  • 中文名稱:
    Recombinant Rat Follicle-stimulating hormone receptor (Fshr)-VLPs
  • 貨號:
    CSB-MP009021RA
  • 規格:
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    FSH-R;Follitropin receptor
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Mammalian cell
  • 表達區域:
    18-692aa
  • 氨基酸序列
    CHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYVLVPLNHSSQN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
  • 基因功能參考文獻:
    1. The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP. PMID: 28605466
    2. Data indicate that sustained follicle stimulation by luteinizing hormone (LH) decreases follicle stimulating hormone (FSH) receptor mRNA levels and FSH receptor signaling and inhibits FSH-induced follicular growth. PMID: 23709086
    3. In 20-day-old rat Sertoli cells, transmembrane cell PGs, through tethering/activation of PP2A activity exerts regulatory control on both FSH receptor/Gs coupling and ERK phosphorylation. PMID: 23500014
    4. Zuoguiyin could improve the ovarian functions during peri-menopause by up-regulating the expression of FSHR. PMID: 20535929
    5. The data suggested that, during prepubertal Sertoli cell maturation, the ability of FSH receptor to respond to FSH is significantly augmented and is associated with the robust differentiation of repopulating spermatogonia. PMID: 22850685
    6. report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter PMID: 22431408
    7. Used immunohistochemistry to study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, and by Western blot analysis in the caput and cauda epididymis of rat. PMID: 20467586
    8. MyH9 constitutively forms a ternary complex with FSH-R and inactive GDP-bound G alpha h. PMID: 20068007
    9. Findings support the concept that thyroid hormone regulates ovarian follicular development and promotes FSH-induced preantral follicular growth through up-regulation of FSHR, a mechanism dependent on the expression and action of oocyte-derived GDF-9. PMID: 19833718
    10. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion PMID: 11934883
    11. differences in hydrophobic interactions between transmembrane domains 6 and 7 of the rat and human FSH receptors PMID: 12145341
    12. downregulation of FSH-FSHR PMID: 12907758
    13. FSH transcytosis across the testicular endothelial barrier is receptor-mediated and involves luminal uptake via coated pits, sorting at the level of luminal early endosomes, and transcellular transport through transcytotic tubulo-vesicular organelles PMID: 15050368
    14. OCT-1 binds within DHS3 to silence Fshr transcription, an activity that involves members of the GATA family PMID: 15817654
    15. FSH up (1.8-fold) regulates its receptor level only in the immature Sertoli cells and not in the adult. PMID: 16406266
    16. FSH receptor expression was demonstrated by RT-PCR and Northern and Western blot analyses in the cauda region of rat epididymis PMID: 16598027
    17. These data reveal that distal regulatory regions are required for appropriate temporal and spatial Fshr expression and implicate the identified evolutionary conserved regions in transcriptional regulation of Fshr. PMID: 17097219
    18. bioneutralization of FSHR has been achieved by targeting its region 285-309 PMID: 17280718
    19. Inhibin A is capable of feedback antagonizing FSH action on GCs by reducing FSHR expression at ovarian level via a short feedback loop. Transcriptional factor receptors, such as SF-1, AR and DAX-1 were involved in this regulation. PMID: 18992787
    20. Results indicate that the charged amino acids present in follicle stimulating hormone receptor peptide (20-30) are crucial for its follicle stimulating hormone antagonistic activity. PMID: 19152639

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 組織特異性:
    Sertoli cells and ovarian granulosa cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 中国少妇xxxx做受| 久久亚洲美女精品国产精品| 无码吃奶揉捏奶头高潮视频| 大又大粗又爽又黄少妇毛片免费| 免费观看成人欧美www色| 一本精品中文字幕在线| 国产v亚洲v天堂无码久久久| 精品久久久久久无码人妻蜜桃| 国产成人亚洲精品无码最新| 亚洲精品国产av现线| 99re6热在线精品视频播放| 国产精品后入内射日本在线观看| 免费国产黄网站在线观看视频| 久久99青青精品免费观看| 日韩欧美偷拍高跟鞋精品一区| 最近中文av字幕在线中文| 性色av无码一区二区三区人妻| 大肉大捧一进一出好爽视频动漫| 久久激情综合狠狠爱五月| 久久99精品国产免费观观| 亚洲一区二区三区偷拍女厕| 亚洲综合无码一区二区三区| 久久婷婷久久一区二区三区| 欧美特黄特色三级视频在线观看 | 亚洲嫩模喷白浆在线观看| 中国产xxxxa片在线观看| 女人被弄到高潮的免费视频| 国产午夜精华2020在线| 国产尤物精品自在拍视频首页| 国产成人免费视频| 日韩精品久久久肉伦网站| 久久国产欧美成人av| 少妇被又大又粗又爽毛片久久黑人| 精品国产乱码久久久久夜深人妻| 国产美足白丝榨精在线观看sm| 亚洲中文字幕av每天更新| 欧美黑人又粗又大的性格特点| 国产精品视频免费播放| 一边啪啪的一边呻吟声口述| 久久天堂av综合合色| 俺去俺来也在线www色官网|