在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Zinc transporter ZIP4 (Slc39a4)

  • 中文名稱:
    小鼠Slc39a4重組蛋白
  • 貨號:
    CSB-CF748511MO
  • 說明書:
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Slc39a4
  • Uniprot No.:
  • 別名:
    Slc39a4; Zip4; Zinc transporter ZIP4; Activated in W/Wv mouse stomach 2; mAWMS2; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    23-660
  • 氨基酸序列
    RPRNLLSLLALGQGALDRLELDGLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPA PESVLESRHIIYLSAAAALYLNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQL LQKIEAHAASQPTGEKTCVDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSP QYFVDFVFRLHSSDPPNITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQD SELHTPHNSNSSVWDTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPY PTIRIQDQLSQTERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGAL TGDALLHLIPKVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLL PRDQDSEKDGPCSHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRL RAELRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALL HAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAM MNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
  • 基因功能參考文獻:
    1. While Zip4 was not found to be essential for proper glucose homeostasis and insulin secretion in vivo in mice, this study found that Zip4 mediates increases in cytoplasmic and granular zinc pools and stimulates glucose dependent insulin secretion in-vitro PMID: 25806541
    2. These studies strongly suggest that wasting and lethality in acrodermatitis enteropathica patients reflects the loss-of-function of the intestine zinc transporter ZIP4, which leads to abnormal Paneth cell gene expression PMID: 22737083
    3. Cell migration assays revealed that RNAi knockdown of Zip4 in Hepa cells depressed in vitro migration whereas forced over-expression in Hepa cells and MCF-7 cells enhanced in vitro migration PMID: 20957146
    4. ZIP4 physically interacts with tPA, correlating with an increased intracellular zinc influx and lysosomal sequestration after excitotoxin stimulation. Changes in prosurvival signals support the idea that this sequestration results in neuroprotection. PMID: 20463217
    5. results provide compelling evidence that ZIP4 is a zinc transporter that plays an important role in zinc homeostasis, a process that is defective in acrodermatitis enteropathica in humans PMID: 12801924
    6. Zinc deficiency increased mZIP4 protein levels at the plasma membrane, and this was associated with increased zinc uptake. PMID: 14612438
    7. ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice PMID: 15358787
    8. that heterozygous mutations in the acrodermatitis gene Zip4 (Slc39a4) may be associated with a wider range of developmental defects than was previously appreciated, particularly when dietary zinc is limiting. PMID: 17483098
    9. ZIP4 is induced by zinc deficiency in cultured mouse Hepa cells and is rapidly degraded in response to added zinc PMID: 18020946
    10. The processing of ZIP4 may represent a significant regulatory mechanism controlling its function. PMID: 18936158
    11. KLF4 is induced during zinc restriction and is a transcription factor involved in adaptive regulation of the zinc transporter ZIP4 PMID: 19147802

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
  • 蛋白家族:
    ZIP transporter (TC 2.A.5) family
  • 組織特異性:
    Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Found to the apical surface of enterocytes and visceral endoderm cells during zinc deficiency.
  • 數據庫鏈接:


主站蜘蛛池模板: 又粗又大又黄又爽的免费视频| 亚洲中文字幕无码天然素人| 国内精品自线一区二区三区2021| 久久久久亚洲精品| 国语精品一区二区三区| 国内精品视频自在一区| 国产福利自产拍| 一区一区三区产品乱码| 国产高清成人免费视频在线观看 | 国产福利一区二区麻豆| 国产欧美精品一区二区三区| 日本sm/羞辱/调教/捆绑视频| 久久五月丁香激情综合| 在线观看国产丝袜控网站| 色噜噜狠狠狠狠色综合久一 | 内射极品少妇xxxxxhd| 国产亚洲成av人片在线观看 | 国产丰满人妻一区二区| 青春草在线视频观看| 毛色毛片免费观看| 久久亚洲精品无码gv| 无码国产成人久久| 最爽free性欧美人妖| 亚洲欧美日韩成人综合一区| 少妇爱做高清免费视频| 久久综合九色综合97欧美| 久久久亚洲欧洲日产国码农村| 亚洲无av码在线中文字幕| av色综合久久天堂av色综合| 51精品国产人成在线观看| 国产在线一区二区av视频| 国产av偷闻女邻居内裤被发现| 99精品众筹模特自拍视频| 国精品无码一区二区三区在线蜜臀| 99久久国产露脸精品| 欧美写真视频在线观看| 精品影片在线观看的网站| 亚洲成色最大综合在线 | 欧美午夜精品一区二区蜜桃| 中文无码一区二区不卡av| 欧美综合自拍亚洲图久青草|