Recombinant Mouse Transmembrane protein 176B (Tmem176b)

in vitro E.coli expression system

中文名稱：

小鼠Tmem176b重組蛋白
貨號：

CSB-CF023758MO
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Tmem176b
Uniprot No.：

Q9R1Q6
別名：

Tmem176b; Clast1; Lr8; Transmembrane protein 176B; Protein LR8
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-263
氨基酸序列

MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLKKFLSWPQARIHYGQLS LGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAILAGVGTIVHEKRQGKLSGQ VSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTCNPLQSSMDPGYGTVRYSDDS DWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVASLGLSLRSMYGRSSQALNEEES ERKLLDGHPAPASPAKEKIPAIL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells.
基因功能參考文獻：
1. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus. PMID: 27009467
2. Tmem176b induces the differentiation of myoblasts into an osteoblast lineage. PMID: 24085390
3. data identify the downregulation of Clast1/LR8 as a potentially important mechanism by which oncogenic Ras-mediated neoplastic transformation occurs PMID: 20550525
4. These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation. PMID: 20501748
5. The Clast1 gene is ubiquitously expressed in various organs of adult mice and is required for development of cerebellar granule cells. PMID: 16814752
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亞細胞定位：

Nucleus membrane; Multi-pass membrane protein.
蛋白家族：

TMEM176 family
組織特異性：

Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:65963

STRING: 10090.ENSMUSP00000098972

UniGene: Mm.28385