在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Selenoprotein S (Sels)

  • 中文名稱:
    小鼠Selenos重組蛋白
  • 貨號(hào):
    CSB-CF857718MO
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Selenos; H47; Vimp; Selenoprotein S; SelS; Minor histocompatibility antigen H47
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-190
  • 氨基酸序列
    MDRDEEPLSARPALETESLRFLHVTVGSLLASYGWYILFSCILLYIVIQRLSLRLRALRQ RQLDQAETVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWD SMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPG RRGPSSGGUN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
  • 基因功能參考文獻(xiàn):
    1. findings suggest that SelS protects endothelial cells against TNF-alpha-induced dysfunction by inhibiting the activation of p38 MAPK and NF-kappaB pathways and implicates it as a possible modulator of vascular inflammatory diseases. PMID: 29805311
    2. the genetic reduction of Seps1 appears to specifically exacerbate the inflammatory profile of fast-twitch muscle fibres, which are typically more vulnerable to degeneration in dystrophy. PMID: 28592916
    3. Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress PMID: 24700463
    4. SelS expression is prominent in neurons and hardly detectable in astrocytes from control mice PMID: 21456042
    5. The SEPS1 protein expression in liver of septic mouse is markedly elevated. PMID: 20979832
    6. Selenoprotein biosynthesis becomes redirected in hepatocytes during the acute-phase response at the expense of dispensable selenoproteins (e.g., SepP) and in favor of SepS expression, thereby causing declining serum selenium and improving liver function. PMID: 20370716
    7. These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction. PMID: 17210132
    8. We found that suppression of SEPS1 by small interfering RNA severely increases astrocyte injure caused by OGD, suggesting that selenoprotein S protects astrocytes against ischemia. PMID: 18498015

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.
  • 蛋白家族:
    Selenoprotein S family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 国产色播av在线观看| 色两性网欧美| 亚洲欧洲美洲无码精品va| 亚洲旡码a∨一区二区三区| 欧美天天拍在线视频| 色综合久久一区二区三区| 黑人大荫蒂高潮视频| 人人妻人人澡人人爽欧美一区九九 | 欧洲黑大粗无码免费| 国产精品无码一区二区在线观一| 色先锋av资源中文字幕| 欧美巨大xxxx做受高清| 亚洲色欲在线播放一区| 怡红院av亚洲一区二区三区h| 疯狂撞击丝袜人妻| 精品麻豆一区二区三区乱码| 69堂人成无码免费视频果冻传媒| 苍井空一区二区波多野结衣av| 日本三级成本人网站| 国产美女a做受大片观看| 国产精品福利一区二区久久| 国产女人和拘做受视频免费| 成人乱人伦视频在线观看| 日韩av无码中文无码电影| 性一交一乱一乱一视频| 又黄又爽又猛的视频免费| 又爽又色禁片1000视频免费看| 伊人久久亚洲综合影院首页| 国产肥白大熟妇bbbb视频| 国产色播av在线观看| 亚洲成成品网站源码中国有限公司| 一二区成人影院电影网| 国产97在线 | 日韩| 97成人精品区在线播放| 男女18禁啪啪无遮挡| 97se亚洲国产综合自在线观看| 五月激激激综合网亚洲| 麻豆国产av尤物网站尤物| 亚洲欧美日韩精品久久亚洲区| 日本熟妇浓密毛毛多| 久久精品亚洲精品无码|