在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Prokineticin receptor 2 (Prokr2)

  • 中文名稱:
    小鼠Prokr2重組蛋白
  • 貨號:
    CSB-CF018749MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Prokr2; Gpr73l1; Pkr2; Prokineticin receptor 2; PK-R2; G-protein coupled receptor 73-like 1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-381
  • 氨基酸序列
    MGPQNRNTSFAPDLNPPQDHVSLNYSYGDYDLPLGEDEDVTKTQTFFAAKIVIGVALAGI MLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWAH GHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSIL IAVPSAYFTTETILVIVKNQEKIFCGQIWSVDQQLYYKSYFLFVFGLEFVGPVVTMTLCY ARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPT VVVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLRLHWRPSHYGSKSSA DLDLKTSGVPATEEVDCIRLK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
  • 基因功能參考文獻:
    1. The sexually dimorphic pattern of Prokr2 expression indicates differential roles in reproductive function and, potentially, in other physiological systems. PMID: 28616754
    2. This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 and PKR2. A truncated anosmin 1 protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 binding. PMID: 27184500
    3. Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease. PMID: 26730729
    4. Studies indicate PK2 signaling is required for the maintenance of normal female estrous cycles. PMID: 24633064
    5. We sought to clarify the role of PROKR2 in hypothalamopituitary development through analysis of Prokr2(-/-) mice. PMID: 23386640
    6. Prokr2 is specifically expressed in the XY gonads during sex determination and fetal sexual differentiation, and knockout mice display a variable degree of compromised vasculature in the fetal testes PMID: 22223120
    7. The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. PMID: 20023120
    8. prokineticin 2 is expressed in neurons of the mouse suprachiasmatic nucleus PMID: 19784373
    9. Phenotypic analysis indicated that not Pkr1(-/-)but Pkr2(-/-)mice exhibited hypoplasia of the olfactory bulb. PMID: 16537498
    10. is an essential link for coordination of circadian behavior and physiology by the suprachiasmatic nucleus, especially in defining the onset and maintenance of circadian night PMID: 17202262
    11. PKR2 expression was maintained over 10.5dpc with both trophoblastic and endothelial cell localisations in mice. PMID: 17531315
    12. Important role for Prokr2 in olfactory bulb neurogenesis. PMID: 18052978
    13. Prokineticin 2 polypeptide (Prokr2) signaling plays a role in hypothalamic regulation of energy balance, and loss of this pathway results in physiological and behavioral responses normally only detected when mice are in negative energy balance. PMID: 18417646
    14. Cardiomyocyte PKR2 signalling leads to eccentric hypertrophy in an autocrine regulation and impaired endothelial integrity in a paracrine regulation without inducing angiogenesis. PMID: 18806277
    15. All mutated PROKR2 except one (M323I) had decreased signalling activities. PMID: 18826963
    16. Results describe the identity of the prokineticin receptor 2-expressing cells in the subventricular zone/rostral migratory stream/olfactory bulb pathway in adult mice. PMID: 19003791
    17. Data show that the inflammation-induced up-regulation of PK2 was significantly less in pkr1 null mice than in WT and pkr2 null mice, demonstrating a role of PKR1 in setting PK2 levels during inflammation. PMID: 19667192

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in several regions of the brain, including paraventricular hypothalamic nucleus, dorsal medial hypothalamic nucleus, paratenial thalamic nuclei, paracentral thalamic nucleus, lateral habenular nucleus, lateral septal nucleus, lateral globus pall
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲人成网77777色在线播放| 2020精品自拍视频曝光| 西西人体大胆午夜啪啪| 超清无码av最大网站| 永久免费毛片在线播放| 亚洲日本精品国产一区vr| 国产乱码二卡3卡四卡| 日本乱子伦一区二区三区| 国产精品久久..4399| 国产av激情无码久久| 日本少妇xxx做受| 人妻无码中文专区久久五月婷| 国产呻吟久久久久久久92| 色情一区二区三区免费看| 97超碰精品成人国产| 国产成人剧情av麻豆果冻| 国产国产裸模裸模私拍视频| 中国娇小与黑人巨大交| 18禁裸体女免费观看| 在线亚洲精品国产一区麻豆 | 色婷婷五月综合色啪网| 中文字幕无码免费久久| 日韩av无码一区二区三区| 中文字幕一二三区波多野结衣| 免费观看男女性高视频| 老熟妇乱子伦牲交视频| 国产成a人亚洲精品无码久久网 | 欧美黑人又粗又硬xxxxx喷水| 国产精品无需播放器在线观看| 欧美性潮喷xxxxx免费视频看| 自拍偷在线精品自拍偷无码专区 | 欧美在线观看免费专区| 久久久噜噜噜久久| 亚洲成a人片在线观看高清| 久久久国产99久久国产久麻豆 | 在线播放国产不卡免费视频| 国产传媒麻豆剧精品av| 男ji大巴进入女人的直播| 综合 欧美 亚洲日本| 中国性少妇内射xxxx狠干| 无码一区二区三区av免费蜜桃|