在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse P2Y purinoceptor 13 (P2yr13)-VLPs

  • 中文名稱:
    Recombinant Mouse P2Y purinoceptor 13 (P2yr13)-VLPs
  • 貨號:
    CSB-MP872011MO
  • 規格:
  • 其他:

產品詳情

  • 基因名:
    P2yr13
  • Uniprot No.:
  • 別名:
    (P2Y13)(G-protein coupled receptor 86)
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 表達區域:
    1-377aa
  • 氨基酸序列
    MLGTINTTGMQGFNKSERCPRDTRMTQLLFPVLYTVVFLAGILLNTVALWVFVHIPSNSTFIVYLKNTLVADLIMALMLPFKILSDSHLAPWQLRGFVCTLSSVVFYETMYVGIMMLGLIAFDRFLKIIMPFRKTFVKKTAFAKTVSISVWSLMFFISLPNMILNKEATPSSVKKCASLKSPLGLWWHQVVSHTCQFIFWAVFILMLLFYAVITKKVYNSYRKFRSKDSRHKRLEVKVFIVMAVFFVCFAPLHFVRIPYTYSQTTNKTDCRLENQLFIAKEATLFLATTNICMDPLIYIILCKKFTQKVPCVRWGKARTAGSSEDHHSSQTDNITLA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
  • 基因功能參考文獻:
    1. Conclude that, at motor nerve terminals, the Gi/o protein-coupled P2Y receptors implicated in presynaptic inhibition of spontaneous and evoked acetylcholine release are of the subtype P2Y13. This study provides new insights into the types of purinergic receptors that contribute to the fine-tuning of cholinergic transmission at mammalian neuromuscular junction. PMID: 27058149
    2. The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary reverse cholesterol transport PMID: 25770145
    3. P2Y13 receptor activation is crucial in mediating the high-fat-diet and palmitic acid-induced myenteric neuronal loss. PMID: 24510452
    4. Up-regulation of HDL-cholesterol metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice. PMID: 24769858
    5. Findings indicate that the P2Y13 R plays an important role in the balance of osteoblast and adipocyte terminal differentiation of bone marrow progenitors. PMID: 23629754
    6. P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development PMID: 24487286
    7. The regulation of P2Y13-R expression and provided evidence that P2Y13-R is tightly regulated by constitutive ubiquitination in the ER, and subsequent proteasome degradation. PMID: 24030815
    8. The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading. PMID: 23362109
    9. results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt-GSK3 pathway PMID: 22250198
    10. P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases. PMID: 22521313
    11. study to examine the role of P2Y13 receptor in bone homeostasis both in vivo and in vitro; deletion of the P2Y13 receptor leads to less trabecular bone in mice, by affecting both osteoblasts and osteoclasts PMID: 22108801
    12. experiments assess a role for the purinergic receptor P2Y(13) in the regulation of lipoprotein metabolism and demonstrate that modulating its activity could be of benefit to the treatment of dyslipidemia in people PMID: 20817122
    13. results show a previously unrecognized role of the purinergic P2Y13 receptor in the induction of the Nrf2/HO-1 antioxidant response and in protection against oxidative stress PMID: 20447456
    14. study shows P2Y(13)-deficient mice exhibited a decrease in hepatic HDL cholesterol uptake, hepatic cholesterol content, and biliary cholesterol output, data indicate P2Y13 activity is involved in macrophage-to-feces reverse cholesterol transport PMID: 20830789
    15. The brackage of P2ry13 protein receptor results in enhanced ERK1/2, Akt/PKB and CREB phosphorylation mechanisms involved in beta-cell survival. PMID: 19915796
    16. (p2y13 purinoceptor) PMID: 11961076

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 国产原创av中文在线观看| 东京热久久综合久久88| 国产成人精品电影在线观看| 亚洲 另类 熟女 字幕| 青春草在线视频免费观看| 亚洲美女精品免费视频| 欧美日韩一卡2卡三卡4卡 乱码欧美孕交 | 99大香伊乱码一区二区| 一区二区国产高清视频在线| 国产精品无码久久久久| 久久久欧美精品激情| 国产色情又大又粗又黄的电影| 亚洲va在线∨a天堂va欧美va| 熟女人妻视频| 国内精品国产成人国产三级| 黄网站色成年片在线观看| 久久久肥妇熟女ⅹxxx毛片| 精品国内在视频线2019| 狠狠色综合网久久久久久 | 七妺福利精品导航大全| 天干夜天天夜天干天2004年| 国产乱人偷精品人妻a片| 精品 在线 视频 亚洲| 动漫成人无码精品一区二区三区| 成人无码视频在线观看网址| 免费做爰猛烈吃奶摸视频在线观看| 色鬼7777久久| 西西人体扒开下部试看120秒 | 免费刺激性视频大片区| 美女mm131午夜福利在线| 亚洲中文字幕无码久久2018| 影音先锋人妻啪啪av资源网站| 性荡视频播放在线视频| 四虎影视无码永久免费| 亚洲精品区午夜亚洲精品区| 激情综合色五月丁香六月亚洲| 亚洲国产成人精品一区刚刚| 男女久久久国产一区二区三区| 国产无遮挡又黄又爽免费视频 | 国产日产欧洲无码视频| 亚洲无日韩码精品|